摘要
在遗传学背景影响下,胚胎发育阶段及出生后发生的胆管壁神经元数量减少、管壁肌纤维发育异常、前肠重复畸形、胆胰管汇合异常等复杂机制,会导致胆管病理性囊状扩张。先天性胆管扩张症作为一种胆管系统癌前病变,非合理的诊疗行为将会加剧胆管囊状扩张症病患发生恶性肿瘤的风险。掌握先天性胆管扩张症继发恶性肿瘤的成因、病理特点及早期确诊技术的局限性,有助于明晰先天性胆管扩张症的诊治要点,降低术后不良治疗事件发生率,规避继发恶性肿瘤的医源性风险。
A complex mechanism of reduced number of bile duct innervating ganglion cells,smooth muscle distribution,foregut duplications,and abnormal pancreaticobiliary duct junction,which occurs during embryonic development and after birth in a genetic context,can lead to pathological congenital biliary dilatation.As a precancerous lesion of the biliary system,irrational treatment of congenital biliary dilatation will further increase the risk of malignancy in patients.By understanding the causes,pathological features,and limitations of early detection techniques of malignant tumor secondary to congenital biliary dilatation is helpful to clarify the key points in the management of congenital biliary dilatation,reduce the incidence of postoperative adverse treatment events and avoid the medical risk of secondary malignancy.
作者
李斌
邱智泉
张吉祥
姜小清
LI Bin;QIU Zhiquan;ZHANG Jixiang;JIANG Xiaoqing(DepartmentⅠof Biliary Tract Surgery,Eastern Hepatobiliary Surgery Hospital&Second Military Medical University Biliary Tract Malignancy Treatment Centre,Secondary Military Medical University,Shanghai 200438,P.R.China)
出处
《中国普外基础与临床杂志》
CAS
2023年第1期12-17,共6页
Chinese Journal of Bases and Clinics In General Surgery
基金
上海市卫健委协同创新计划(项目编号:2019CXJQ03)
上海市科委科技支撑-西医引导类项目(项目编号:19411967000)
孟超人才计划项目(项目编号:中青年英才-2019)。
关键词
先天性胆管扩张症
恶性肿瘤
congenital biliary dilatation
malignant tumor
