摘要
脓毒症相关性脑病(SAE)发病机制复杂,死亡率高,传统的临床干预手段简单且有限,存活患者可能会发生长期认知功能障碍。核转录因子-E2相关因子2(Nrf2)是抗氧化和抗炎机制的中心调节因子,研究表明Nrf2可调节多种信号通路改善SAE预后和认知功能。因此Nrf2可能是SAE潜在的治疗靶点,Nrf2激活剂可能是SAE有前景的新型治疗策略。文章主要就Nrf2及其通路在SAE中的调节机制及Nrf2激活剂的研究进展进行综述。
Sepsis-associated encephalopathy(SAE)has complex pathogenesis and high mortality.Traditional clinical interventions are simple and limited,and surviving patients may develop long-term cognitive dysfunction.Nuclear factor erythroid 2-related factor 2(Nrf2)is a central regulator of antioxidant and anti-inflammatory mechanisms,and studies have shown that Nrf2 can regulate multiple signaling pathways to improve prognosis and cognitive function of SAE.Therefore,Nrf2 may be a potential therapeutic target for SAE.Nrf2 activator may be a promising novel therapeutic strategy for SAE.This review focuses on the regulatory mechanism of Nrf2 and the related pathways in SAE and the research progress of Nrf2 activator.
作者
孟小舟(综述)
张利东(审校)
MENG Xiao-zhou;ZHANG Li-dong(Department of Anesthesiology,Jinling Hospital,Jinling School Clinical Medicine,Nanjing Medical University/Gen-eral Hospital of Eastern Theater Command,PLA,Nanjing 210002,Jiangsu,China)
出处
《东南国防医药》
2022年第6期636-641,共6页
Military Medical Journal of Southeast China
基金
军委后勤保障部卫生局军事医学创新工程专项基金(20WQ025)。
