摘要
手足口病(hand,foot and mouth disease,HFMD)严重影响着婴幼儿健康。肠道病毒A组71型(enterovirus A71,EV71)及柯萨奇病毒A组16型(coxsackievirus A16,CA16)是引起手足口病的主要病原体,曾在全球多个国家或地区暴发,接种疫苗是预防手足口病的有效途径,EV71疫苗已上市,但是CA16疫苗相关研发进展较缓慢,目前仍无相关疫苗上市。本文对CA16型灭活疫苗、减毒活疫苗、病毒样颗粒(virus-like particle,VLP)疫苗、DNA疫苗、重组嵌合病毒疫苗及亚单位疫苗的相关研究进展做一综述。
Hand, foot and mouth disease( HFMD) is an infectious disease that seriously affects the health of infants and young children. Enterovirus A71( EV71) and Coxsackievirus A16( CA16) are the main pathogens causing HFMD. HFMD has been outbreaks in many countries or regions around the world. Vaccination is an effective way to prevent HFMD. EV71vaccine has been marketed, but CA16 vaccine research and development progress is relatively slow. So far, there is still no CA16-related vaccine on the market. This article reviews the research progress of CA16 inactivated vaccine, live attenuated vaccine, virus-like particle( VLP) vaccine, DNA vaccine, recombinant chimeric virus vaccine and subunit vaccine.
作者
王乾芬
原国强
吴羽晨
徐萍
徐小博
WANG Qian-fen;YUAN Guo-qiang;WU Yu-chen;XU Ping;XU Xiao-bo(School of Life Sciences&Basic Medicine,Xinxiang University,Henan 453003,China;不详)
出处
《安徽预防医学杂志》
2022年第6期487-489,522,共4页
Anhui Journal of Preventive Medicine
关键词
手足口病
肠道病毒
柯萨奇病毒A组16型
疫苗
Hand
foot and mouth disease’Enterovirus’Coxsackievirus group A 16’Vaccine
