摘要
目的:探讨卡前列素氨丁三醇联合球囊压迫对前置胎盘剖宫产产后出血患者凝血功能及应激状态的影响。方法:选取2017年5月-2022年5月本院收治的前置胎盘剖宫产产后出血患者84例,随机数字表法分为对照组和联合组各42例,两组均给予一次性宫腔球囊压迫治疗,联合组给予前列素氨丁三醇联合治疗。比较两组出血量、凝血功能、应激状态及并发症情况。结果:对照组产时(381.52±45.15 ml)、产后2h(296.47±38.15 ml)、产后24h(352.14±41.16 ml)出血量均高于联合组(235.74±34.61 ml、198.74±27.16 ml、273.06±36.15 ml)(P<0.05)。两组治疗后血清纤维蛋白原水平、凝血酶原时间、活化部分凝血活酶时间均降低且联合组(3.17±0.43 g/L、10.16±1.13s、37.04±3.08s)低于对照组(4.25±0.62 g/L、13.74±1.21s、45.17±3.41s),血清去甲肾上腺素、肾上腺素、皮质醇水平均升高但联合组(297.45±28.66 pg/ml、52.65±6.47 pg/ml、274.26±35.21 ng/ml)低于对照组(354.06±34.12 pg/ml、69.58±7.21 pg/ml、327.28±43.05 ng/ml)(均P<0.05)。并发症发生率对照组(19.0%)与联合组(9.5%)无差异(P=0.212)。结论:卡前列素氨丁三醇联合球囊压迫治疗前置胎盘剖宫产产后出血效果提高,能够改善患者凝血功能,有效控制患者应激状态,安全性较好。
Objective:To explore the effects of carboprost tromethamine combined with balloon compression for treating post-cesarean hemorrhage of women with placenta previa on their coagulation function and stress state.Methods:A total of 84 women with postpartum hemorrhage after cesarean section due to placenta previa were selected and divided into two groups(42 cases in each group)by random number table from May 2017 to May 2022.The women in the control group were given one-time intrauterine balloon compression therapy,while the women in the observation group were given prostaglandin tromethamine combined with balloon compression therapy.The blood loss,coagulation function,stress state,and complications situation of the women were compared between the two groups.Results:The blood loss of the women in the control group during delivery(381.52±45.15 ml),postpartum 2h(296.47±38.15 ml),and postpartum 24h(352.14±41.16 ml)were significantly more than those(235.74±34.61 ml and 198.74±27.16 ml,and 273.06±36.15 ml)of the women in the observation group(P<0.05).The serum fibrinogen level,the prothrombin time,and activated partial thrombin time of the women in the two groups after treatment had decreased significantly,and which(3.17±0.43 g/L,10.16±1.13s,and 37.04±3.08s)of the women in the observation group were significantly lower than those(4.25±0.62g/L,13.74±1.21s,and 45.17±3.41s)of the women in the control group.The levels of serum norepinephrine,epinephrine,and cortisol of the women in the two groups after treatment had increased significantly,but which(297.45±28.66pg/ml,52.65±6.47pg/ml,and 274.26±35.21ng/ml)of the women in the observation group were significantly lower than those(354.06±34.12pg/ml,69.58±7.21pg/ml,and 327.28±43.05ng/ml)of the women in the control group(all P<0.05).The complication rate(9.5%)of the women in the observation group had no significantly different from that(19.0%)of the women in the control group(P=0.212).Conclusion:Carboprost tromethamine combined with balloon compression for treating
作者
牛昱欣
王艳华
张燕怡
刘谡
曹迪
李娟
NIU Yuxin;WANG Yanhua;ZHANG Yanyi;LIU Su;CAO Di;LI Juan(Sami Medical Center(The Fourth People's Hospital of Shenzhen),Shenzhen,Guangdong Province,518000;The Third Affiliated Hospital of Qiqihar Medical College,Qiqihar,Heilongjiang Province;The First Hospital of Qiqihar,Heilongjiang Province)
出处
《中国计划生育学杂志》
2023年第1期108-111,116,共5页
Chinese Journal of Family Planning
关键词
前置胎盘
产后出血
卡前列素氨丁三醇
球囊压迫
凝血功能
应激状态
Placenta previa
Postpartum hemorrhage
Carboprost tromethamine
Balloon compression
Coagulation function
Stress state
