摘要
目的探讨血脂指标及其比值与青年脑梗死之间的关系及临床意义。方法选取2021年1月至2021年12月在阜新市中心医院神经内科住院的青年脑梗死患者226例作为研究组,选取同期健康体检者143例作为对照组,收集所有研究对象的一般资料,如吸烟史、饮酒史和高血压史,以及总胆固醇(total cholesterol,TC)、甘油三酯(triglyceride,TG)、高密度脂蛋白胆固醇(high-density lipoprotein cholesterol,HDL-C)和低密度脂蛋白胆固醇(low-density lipoprotein cholesterol,LDL-C)等数据,计算TG/HDL-C、TC/HDL-C和LDL-C/HDL-C比值。通过Logistic回归分析和ROC分析评价血脂指标及其比值在青年脑梗死发生中的作用。结果(1)与对照组相比,研究组患者的年龄、性别和TC差异无统计学意义(P>0.05);伴随高血压、吸烟和饮酒者的比例及TG、LDL-C、TG/HDL-C、TC/HDL-C和LDL-C/HDL-C水平均明显增高,差异显有统计学意义(P<0.05);而HDL-C水平明显降低,具有统计学意义(P<0.05);(2)多因素Logistic回归分析发现高血压(OR=1.97,P=0.011)、吸烟(OR=2.54,P=0.001)、TG(OR=2.24,P<0.001)、LDL-C(OR=0.46,P=0.001)和LDL-C/HDL-C(OR=3.39,P<0.001)与青年脑梗死的发生显著相关,是青年脑梗死发生的独立危险因素;(3)ROC曲线分析显示,TG的AUC为0.793,敏感度为0.742、特异度为0.729;LDL-C/HDL-C的AUC为0.801,敏感度为0.692、特异度为0.800。结论(1)高血压、吸烟、TG、LDL-C、和LDL-C/HDL-C是青年脑梗死发生的独立危险因素;(2)血脂指标TG和LDL-C/HDL-C对青年脑梗死的发生具有一定的预测作用。
Objective To investigate the relationship and clinical significance of serum lipid index and its ratio with cerebral infarction in young people.Methods A total of 226 young patients with cerebral infarction who were admitted to the Department of Neurology of Fuxin Central Hospital from January 2021 to December 2021 were selected as the study group,and 143 healthy subjects were selected as the control group.General information was collected on all participants,including history of smoking,alcohol consumption and hypertension.Total cholesterol(TC),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C)and low-density lipoprotein(LDL-C)were measured,and TG/HDL-C,TC/HDL-C and LDL-C/HDL-C were calculated.Logistic regression analysis and ROC analysis were used to evaluate the predictive value of serum lipid index and its ratio in young patients with cerebral infarction.Results(1)Compared with the control group,there were no significant differences in age,gender and TC in the study group(P>0.05);the proportion of patients with hypertension,smoking and alcohol consumption and the levels of TG,LDL-C,TG/HDL-C,TC/HDL-C and LDL-C/HDL-C were significantly increased(P<0.05);the HDL-C level was significantly decreased(P<0.05);(2)multivariate logistic regression analysis found that hypertension(OR=1.97,P=0.011),smoking(OR=2.54,P=0.001),TG,(OR=0.46,P=0.001)LDL-C(OR=0.46,P=0.001)and LDL-C/HDL-C(OR=3.39,P<0.001)were significantly correlated with the occurrence of cerebral infarction in young people,and were independent risk factors for the occurrence of cerebral infarction in young people;(3)ROC curve analysis showed that the AUC,sensitivity and specificity of TG were 0.793,0.742 and 0.729,respectively.The AUC,sensitivity and specificity of LDL-C/HDL-C were 0.801,0.692 and 0.800,respectively.Conclusion(1)Hypertension,smoking,TG,LDL-C,and LDL-C/HDL-C are independent risk factors for cerebral infarction in young people,and are involved in the pathogenesis of cerebral infarction in young people;(2)TG and TG/HDL-C,TC/HDL-C and LDL
作者
李思儒
刘峻峰
郭丰
闵连秋
Li Siru;Liu Junfeng;Guo Feng;Min Lianqiu(Postgraduate Training Base of Jinzhou Medical University,Fuxin Central Hospital,Fuxin 123000 China;Xifeng County Vocational and Technical Secondary School,Tieling 112400 China;Department of Neurology,the First Affiliated Hospital of Jinzhou Medical University,Jinzhou 121000 China)
出处
《锦州医科大学学报》
2022年第6期46-50,共5页
Journal of Jinzhou Medical University
基金
辽宁省自然科学基金指导计划项目,项目编号:20170540379。
关键词
血脂指标
血脂比值
青年
脑梗死
blood lipid
blood lipid ratio
the young
cerebral infarction
