摘要
目的观察耳穴埋针联合药物治疗小儿过敏性鼻炎-哮喘综合征(combined allergic rhinitis and asthma syndrome,CARAS)的临床疗效及对肺功能和血清免疫球蛋白E(immunoglobulin E,IgE)、嗜酸性粒细胞(eosinophilic,EOS)、呼出气一氧化氮(fractional exhaled nitric oxide,FeNO)的影响。方法将84例CARAS患者随机分为观察组和对照组,每组42例。对照组予布地奈德雾化吸入,孟鲁司特钠睡前口服治疗;在此基础上观察组予耳穴埋针治疗。观察两组主要症状(鼻塞、鼻痒、喷嚏、清涕、气喘、胸闷、咳嗽、喉间痰鸣)积分、肺功能指标[(1秒用力呼气容积(forced expiratory volume in one second,FEV1)、用力肺活量(forced vital capacity,FVC)、FEV1/FVC、呼气峰流速(peak expiratory flow,PEF)]及血清Ig E、EOS和FeNO水平变化,并比较两组临床疗效。结果观察组总有效率为90.5%,与对照组的71.4%比较,差异有统计学意义(P<0.01)。治疗后,观察组主要症状积分均较治疗前改善,且治疗组优于对照组,差异有统计学意义(P<0.01)。治疗后,两组肺功能指标、血清Ig E、EOS和Fe NO水平与治疗前比较,差异均有统计学意义(P<0.01);且治疗组均优于对照组,差异有统计学意义(P<0.05)。结论耳穴埋针联合药物治疗小儿CARAS疗效显著,不仅能够改善患者鼻炎、哮喘症状,且能有效促进肺功能恢复,改善血清IgE、EOS和FeNO水平。
Objective To observe the clinical efficacy of needle embedding at auricular points plus medications in treating combined allergic rhinitis and asthma syndrome(CARAS)and its effects on pulmonary function,the levels of serum immunoglobulin E(IgE),eosinophil,and fractional exhaled nitric oxide(FeNO).Method Eighty-four CARAS patients were randomly divided into an observation group and a control group,with 42 cases in each group.The control group was treated with Budesonide inhalation and oral Montelukast sodium tablets before bedtime;the observation group received additional needle embedding at auricular points.Changes in the main symptom scores(stuffy nasal,itchy nose,sneezing,runny nose,panting,chest tightness,cough,and gurgling with sputum),pulmonary function indicators[forced expiratory volume in one second(FEV1),forced vital capacity(FVC),FEV1/FVC,and peak expiratory flow(PEF)],the levels of serum IgE and EOS,and FeNO were observed,and the clinical efficacy was also compared.Result The total effective rate was 90.5%in the observation group versus 71.4%in the control group,and the difference was statistically significant(P<0.05).The main symptom scores were improved after the treatment in the observation group and were better than those in the control group,showing statistical significance(P<0.01).After the treatment,the pulmonary function indicators,serum IgE and EOS,and FeNO changed significantly in both groups(P<0.01);the observation group was superior to the control group,showing statistical significance(P<0.01).Conclusion Needle embedding at auricular points plus medications can produce significant efficacy in treating children’s CARAS;it can improve rhinitis and asthma symptoms,effectively boost the recovery of pulmonary function,and improve serum IgE and EOS and FeNO.
作者
薛玉
麦雄燕
符慧玉
莫李媚
蒋林海
XUE Yu;MAI Xiongyan;FU Huiyu;MO Limei;JIANG Linhai(Sanya Women and Children’s Hospital,Shanghai Children’s Medical Center,Sanya 572000,China)
出处
《上海针灸杂志》
CSCD
2023年第1期30-35,共6页
Shanghai Journal of Acupuncture and Moxibustion
基金
三亚市医疗卫生科技创新项目(2018YW24)。
关键词
皮内针疗法
揿针
耳穴
鼻炎
变应性
哮喘
综合征
肺功能
免疫球蛋白E
嗜酸性粒细胞
呼出气一氧化氮
Intradermal needle therapy
Thumbtack needle
Auricular points
Rhinitis
Allergic
Asthma
Syndrome
Pulmonary function
Immunoglobulin E
Eosinophil
Fractional exhaled nitric oxide
