摘要
临床中脑小血管病患者发生自发性高血压脑出血的现象多见,且很多患者合并脑小血管病的影像学标志物,本综述对二者临床上的相关性进行总结。脑白质高信号的严重程度与自发性高血压脑出血复发的风险呈正相关,增加死亡率和不良预后;总微出血数量与血肿扩大显著相关,可预测患者的不良预后;血管周围间隙扩大或腔隙性梗死合并自发性高血压脑出血的临床研究较少,有待于进一步阐明;多个影像学特征的脑小血管病患者,其脑小血管病总体负荷评分越高,临床不良功能预后及脑出血复发风险越高。
Many patients with cerebral small vessel disease(CSVD) in clinical practice developed spontaneous hypertensive intracerebral hemorrhage, and many CSVD patients had CSVD imaging markers. This article reviewed the progress of clinical correlation of spontaneous intracerebral hemorrhage with CSVD. Most studies suggested that the severity of white matter hyperintensity was positively correlated with the risk of intracerebral hemorrhage recurrence,and increased mortality and poor prognosis;the total number of microbleeds was significantly correlated with hematoma enlargement, and could predict the poor prognosis of patients. There are few studies on the correlation of enlarged perivascular space or lacunar infarction with spontaneous hypertensive intracerebral hemorrhage, and the evidence on their relationship is insufficient. For patients with multiple CSVD imaging features, the higher the total score of CSVD load, the higher the risk of poor functional prognosis and intracerebral hemorrhage recurrence.
作者
郑占军
赵性泉
ZHENG Zhanjun;ZHAO Xingquan(Department of Neurology,Beijing Tiantan Hospital,Capital Medical University,Beijing 100070,China;Department of Neurology,Hebei Yanda Hospital,Langfang 065201,China)
出处
《中国卒中杂志》
2022年第12期1396-1402,共7页
Chinese Journal of Stroke
关键词
脑小血管病
高血压脑出血
脑小血管病负荷
脑白质高信号
脑微出血
血管周围间隙扩大
腔隙性梗死
Cerebral small vessel disease
Hypertensive intracerebral hemorrhage
Cerebral small vessel disease load
White matter hyperintensity
Cerebral microbleed
Enlarged perivascular space
Lacunar infarct
