摘要
急性缺血性脑卒中(AIS)病死率、致残率高,是世界范围内的主要死亡及残疾原因之一。中性粒细胞作为机体免疫防御的第一道防线,参与了多种疾病的发生发展。近年来有研究证实,活化的中性粒细胞可产生中性粒细胞胞外诱捕网(NETs),促使脑血栓的形成,进而参与急性缺血性脑卒中的发生发展,但发病机制尚未阐明。本文将围绕最近的研究,详述中性粒细胞及NETs在急性缺血性脑卒中的作用、对预后的影响、治疗的意义。
Acute ischemic stroke(AIS)is one of the major causes of death and disability worldwide with high mortality and disability rate.Neutrophils,as the first line of immune defense,participate in the occurrence and development of many diseases.In recent years,studies have confirmed that activated neutrophils can produce neutrophil extracellular traps(NETs),promote the formation of cerebral thrombus,and then participate in the occurrence and development of acute ischemic stroke,but the pathogenesis has not yet been elucidated.This article will focus on recent studies to detail the role of neutrophils and NETs in acute ischemic stroke,their impact on prognosis,and the significance of treatment.
作者
徐跃轩
赵晓丽
XU Yuexuan;ZHAO Xiaoli(Department of Clinical Laboratory,the Ganmei Hospital Affiliated of Kunming Medical University,Kunming,Yunnan,China,650000)
出处
《分子诊断与治疗杂志》
2022年第12期2219-2222,共4页
Journal of Molecular Diagnostics and Therapy
基金
云南省教育厅科学研究基金项目(2022Y198)
昆明市西山区科技计划项目(西科字23号)。
