摘要
目的 观察尼可地尔联合单硝酸异山梨酯治疗冠心病心绞痛的临床效果。方法 80例冠心病心绞痛患者,使用随机数字表法分为对照组和观察组,各40例。对照组患者使用单硝酸异山梨酯进行治疗,观察组患者使用尼可地尔联合单硝酸异山梨酯进行治疗。对比两组临床效果、心绞痛缓解时间及血压情况。结果 观察组治疗总有效率为97.50%,高于对照组的82.50%,差异有统计学意义(P<0.05)。观察组心绞痛缓解时间(25.24±3.42)min短于对照组的(47.65±5.56)min,舒张压(83.45±5.52)mm Hg(1 mm Hg=0.133 kPa)、收缩压(122.13±3.42)mm Hg低于对照组的(98.17±7.47)、(138.79±10.05)mm Hg,差异有统计学意义(P<0.05)。结论 冠心病心绞痛患者采取尼可地尔联合单硝酸异山梨酯治疗临床效果显著,可缩短患者心绞痛缓解时间,改善患者血压情况,值得推广。
Objective To observe the clinical effect of nicorandil combined with isosorbide mononitrate in the treatment of angina pectoris of coronary heart disease. Methods A total of 80 patients with angina pectoris of coronary heart disease were randomly divided into the control group and the observation group, with 40 patients in each group. Patients in the control group were treated with isosorbide mononitrate, while patients in the observation group were treated with nicorandil combined with isosorbide mononitrate. The clinical effect,remission time of angina pectoris and blood pressure of the two groups were compared. Results The total effective rate in the observation group was 97.50%, which was higher than 82.50% in the control group, and the difference was statistically significant(P<0.05). The remission time of angina pectoris in the observation group was(25.24±3.42) min, which was shorter than(47.65±5.56) min in the control group;the diastolic blood pressure(83.45±5.52) mm Hg(1 mm Hg=0.133 kPa) and systolic blood pressure(122.13±3.42) mm Hg in the observation group were lower than(98.17±7.47) and(138.79±10.05) mm Hg in the control group;the differences were statistically significant(P<0.05). Conclusion In the treatment of patients with angina pectoris of coronary heart disease, the combination of nicorandil and isosorbide mononitrate has a high clinical effect, and can shorten the remission time of angina pectoris and improve their blood pressure, which is worthy of promotion.
作者
王超
WANG Chao(Kazuo Traditional Chinese Medicine Hospital,Chaoyang 122300,China)
出处
《中国现代药物应用》
2023年第1期82-84,共3页
Chinese Journal of Modern Drug Application
关键词
冠心病心绞痛
尼可地尔
单硝酸异山梨酯
治疗效果
Angina pectoris of coronary heart disease
Nicorandil
Isosorbide mononitrate
Therapeutic effect
