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阻塞性睡眠呼吸暂停低通气综合征患者认知障碍及相关因素分析 被引量:3

Cognitive impairment in patients with obstructive sleep apnea hypopnea syndrome and analysis of the related factors
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摘要 目的 了解阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者认知障碍特点及相关因素。方法 回顾性选择2021年2月至2022年4月就诊于黄河三门峡医院睡眠中心的56例患者作为研究对象,依据多导睡眠监测(PSG)结果中呼吸暂停低通气指数(AHI)分为:OSAHS组(AHI≥5次/h)30例,非OSAHS组(AHI<5次/h)26例。比较两组PSG参数[AHI、最低氧饱和度(LSaO2)、氧减饱和度指数(ODI)、快速眼球运动(REM)期睡眠比例(REM%)、Ⅰ+Ⅱ期睡眠比例(Ⅰ%+Ⅱ%)、Ⅲ期睡眠比例(Ⅲ%)]、MoCA量表评分、血清S100β、神经元特异性烯醇化酶(NSE)、白细胞介素-6(IL-6)水平之间的差异,并分析OSAHS患者认知障碍相关影响因素。结果 PSG相关参数比较中,OSAHS组患者AHI、ODI、Ⅰ%+Ⅱ%高于非OSAHS组,LSaO2、REM%、Ⅲ%低于非OSAHS组,差异均有统计学意义(P<0.05)。MoCA量表总得分以及各亚认知域的得分,包括视空间与执行力、命名能力、注意力、语言能力、抽象思维、记忆力、定向力等方面,OSAHS组低于非OSAHS组,差异均有统计学意义(P<0.05)。OSAHS组患者血清S100β、IL-6水平明显高于非OSAHS组,差异均有统计学意义(P<0.05),两组血清NSE比较,差异无统计学意义(P>0.05)。OSAHS患者MoCA总分与年龄、体重指数、AHI、ODI、Ⅰ%+Ⅱ%、血清S100β、IL-6水平呈负相关(r=-0.271、-0.218、-0.564、-0.221、-0.315、-0.382、-0.815,均P<0.05),与LSaO2、REM%、Ⅲ%呈正相关(r=0.362、0.257、0.392,均P<0.05)。结论 OSAHS患者的认知障碍表现在MoCA量表中各个亚认知域,且与年龄、体重指数、PSG中的诸多参数以及血清S100β、IL-6相关,血清S100β、IL-6可作为评估OSAHS患者脑损伤以及认知障碍的敏感指标。 Objective To understand the characteristics and related factors of cognitive impairment in patients with obstructive sleep apnea hypopnea syndrome(OSAHS). Methods Fifty six patients who visited the sleep center of Huanghe Sanmenxia Hospital from February 2021 to April 2022 were retrospectively selected as the study subjects, according to the results of polysomnography(PSG), the apnea hypopnea index(AHI) was divided into 30 patients in OSAHS group(AHI≥5 times/h) and 26 patients in non OSAHS group(AHI<5 times/h). PSG parameters[AHI, lowest oxygen saturation(LSaO2), oxygen desaturation index(ODI), rapid eye movement(REM) stage sleep ratio(REM%), Ⅰ+Ⅱstage sleep ratio(Ⅰ%+Ⅱ%), Ⅲ stage sleep ratio(Ⅲ%)], MoCA scale score, serum S100β, neuron-specific enolase(NSE) and interleukin-6(IL-6) levels, and the influencing factors related to cognitive impairment in OSAHS patients were compared between the two groups. Results AHI, ODI andⅠ%+Ⅱ% in OSAHS group were higher than those in non-OSAHS group, while LSaO2, REM% and Ⅲ% were lower than those in non-OSAHS group, the differences were statistically significant(P<0.05). The total score of MoCA scale and scores of subcognitive domains, including visual space and executive ability, naming ability, attention, language ability, abstract thinking, memory and orientation, were lower in the OSAHS group than those in the non-OSAHS group, the differences were statistically significant(P<0.05). Serum S100β, NSE and IL-6 levels in OSAHS group were significantly higher than those in non-OSAHS group, the differences were statistically significant(P<0.05), while there was no significant difference in serum NSE between the two groups(P>0.05). The total MoCA score of OSAHS patients was negatively correlated with age, body mass index, AHI, ODI, Ⅰ%+Ⅱ%, serum S100β and IL-6 levels(r=-0.271,-0.218,-0.564,-0.221,-0.315,-0.382,-0.815, P<0.05), and positively correlated with LSaO2, REM % and Ⅲ%(r=0.362, 0.257, 0.392, P<0.05). Conclusion Cognitive impairment in patients with
作者 黄敏 薛萌 程小宪 石磊 兰梦宇 HUANG Min;XUE Meng;CHENG Xiao-xian(Department of Respiratory and Critical Care Medicine,Huanghe Sanmenxia Hospital,Sanmenxia Henan 472000,China;Department of Neurology,Huanghe Sanmenxia Hospital,Sanmenxia Henan 472000,China)
出处 《临床和实验医学杂志》 2022年第24期2595-2599,共5页 Journal of Clinical and Experimental Medicine
基金 河南省社发领域科技攻关项目(编号:152102310220)。
关键词 阻塞性睡眠呼吸暂停低通气综合征 认知障碍 相关因素 Obstructive sleep apnea hypopnea syndrome Cognitive impairment Related factors
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