摘要
目的探讨玻璃酸钠联合硫酸氨基葡萄糖治疗膝关节骨关节炎患者的疗效。方法选取2020年1-6月岱山县中医院骨伤科就诊的90例门诊和住院膝关节骨关节炎患者,采用随机数字表法分为玻璃酸钠组(对照组)和玻璃酸钠联合硫酸氨基葡萄糖组(观察组),每组45例。分别于治疗前及治疗后5周、6个月,采用视觉模拟量表(VAS)评分评估两组患者疼痛变化情况;同时,比较两组患者治疗后5周、6个月治疗总有效率。结果治疗前,两组患者VAS评分[(7.4±1.5)比(7.3±1.7)分]比较差异无统计学意义(t=0.24,P=0.812);治疗后5周[(5.3±1.1)比(4.1±1.2)分]、6个月[(4.0±0.8)比(3.2±0.9)分],观察组患者VAS评分均明显低于对照组,差异均有统计学意义(t=5.54、5.32,P均<0.001)。与同组治疗前比较,两组患者治疗后5周、6个月VAS评分均较低,差异均有统计学意义(P均<0.05)。治疗后5周,两组患者治疗总有效率[44.4%(20/45)比48.9%(22/45)]比较差异无统计学意义(χ^(2)=0.18,P=0.672);治疗后6个月,观察组治疗总有效率(91.1%,41/45)明显高于对照组(66.7%,30/45),差异有统计学意义(χ^(2)=8.07,P=0.004)。结论玻璃酸钠联合硫酸氨基葡萄糖治疗膝关节骨关节炎能够明显减轻患者疼痛程度,治疗总有效率较高,且优于单独使用玻璃酸钠治疗效果。
Objective To explore the therapeutic effect of sodium hyaluronate combined with glucosamine sulfate in the treatment of knee osteoarthritis.MethodsA total of 90 outpatients and inpatients with knee osteoarthritis who visited the Department of Orthopedics and Traumatology,Daishan County Hospital of Traditional Chinese Medicine from January to June 2020 were selected,and they were divided into sodium hyaluronate group(control group)and sodium hyaluronate combined with glucosamine sulfate group(observation group)by random number table method,with 45 patients in each group.Visual analog scale(VAS)score was used to evaluate the changes of pain in the two groups before treatment,5 weeks and 6 months after treatment,respectively;at the same time,the total effective rate of 5 weeks and 6 months after treatment was compared between the two groups.Results Before treatment,there was no significant difference in VAS scores[(7.4±1.5)vs(7.3±1.7)points]between the two groups(t=0.24,P=0.812);at 5 weeks[(5.3±1.1)vs(4.1±1.2)points]and 6 months afer treatment[4.0±0.8)us(3.2±0.9)points],the VAS scores of the observation group were significantly lower than those of the control group,and the differences were statistically significant(t=5.54,5.32,P<0.001).Compared with the same group before treatment,VAS scores were lower in the two groups at 5 weeks and 6 months after treatment,and the differences were statistically significant(P<0.05).At 5 weeks after treatment,there was no significant difference in the total effective rates[44.4%(20/45)vs 48.9%(22/45)]between the two groups(χ^(2)=0.18,P=0.672);at 6 months after treatment,the total effective rate of the observation group(91.1%,41/45)was significantly higher than that of the control group(66.7%,30/45),and the difference was statistically significant(χ^(2)=8.07,P=0.004).Conclusion Sodium hyaluronate combined with glucosamine sulfate can significantly reduce the pain in patients with knee osteoarthritis,the total effective rate is higher,and is better than the effect of sodium h
作者
戎霞婉
应肖蓉
邹丽芳
罗雄生
Rong Xiawan;Ying Xiaorong;Zou Lifang;Luo Xiongsheng(Department of Orthopedics and Traumatology,Daishan County Hospital of Traditional Chinese Medicine,Zhoushan 316200,China)
出处
《中华地方病学杂志》
CAS
北大核心
2022年第10期837-840,共4页
Chinese Journal of Endemiology
关键词
骨关节炎
膝
玻璃酸钠
硫酸氨基葡萄糖
Osteoarthritis,knee
Sodium hyaluronate
C
lucosamine sulfate
