摘要
目的 了解长期高频次捐献单采血小板对献血者健康安全与血小板质量的影响。方法 从2020年8月~2022年7月在本站捐献单采血小板的献血者中,分别选择捐献20~29次与30~44次者为2组对象,收集2组献血者最近连续捐献的20、30次的红细胞计数(RBC)、血红蛋白(Hb)、血细胞比容(Hct)、平均红细胞体积(MCV)、血小板计数(Plt)、白细胞计数(WBC)、大血小板比率(P-LCR),淋巴细胞(LYM)、中性粒细胞(NE)、平均血红蛋白含量(MCH)、平均血红蛋白浓度(MCHC)、血小板比容(PCT)、平均血小板体积(MPV)、血小板分布宽度(PDW)共14项检测指标,按5次/组做分组统计分析。另外选择在本站捐献单采血小板次数≥100次献血者,分析其RBC、Hb、Hct、PLT、WBC 5项参数的变化及与献血小板总次数的相关性,选取前100次数据,按10次/组做分组统计分析。结果 2年捐献单采血小板20~29次组有30人、30~44次组有11人,2组各血液学参数均未见明显改变(P>0.05);捐献血小板总次数≥100次献血者RBC、Hb、Hct、WBC与献血次数呈负相关,Plt与献血次数呈正相关,各组间Hb、Hct、WBC、Plt有明显差异(P<0.05)。Hb、Hct、WBC呈下降趋势,Plt呈上升趋势。结论 长期高频次捐献单采血小板捐献者随着献血次数和总量的增加,会引起部分血液学参数的改变;须加强监测和健康宣教,以保障献血者安全和血液质量。
Objective To understand the effect of long-term high-frequency platelet donation on the health, safety and platelet quality of blood donors. Methods From August 2020 to July 2022, blood donors who donated platelets for single collection in the station were selected as two groups: those who donated for 20-29 times and those who donated for 30-44 times. Such 14 test indexes as red blood cell count(RBC), hemoglobin(Hb), hematocrit(Hct), mean corpuscular volume(MCV), platelet count(Plt), white blood cell count(WBC), large platelet ratio(P-LCR), lymphocyte(LYM), neutrophil(NE), mean hemoglobin content(MCH), mean hemoglobin concentration(MCHC), platelet specific volume(PCT), mean platelet volume(MPV) and platelet distribution width(PDW) were grouped and statistically analyzed for 5 times in each group. In addition, blood donors who have donated platelets more than 100 times in the station were chosen;the changes of their 5 parameters as RBC, Hb, Hct, PLT and WBC, as well as the correlation with the total number of platelet donations were analyzed through statistical analysis of the first 100 donations(10 donations/group). Results During 2 years, the hematological parameters were similar between 20-29 donation group(n=30) and 30-44 donation group(n=11)(P>0.05). For donors with donations≥100 occasions, RBC, Hb, Hct and WBC were negatively correlated with the number of blood donations, while Plt was positively correlated. There were significant differences in Hb, Hct, WBC and Plt among groups(P<0.05). Hb, Hct and WBC showed a downward trend, while Plt showed an upward trend. Conclusion With the increase of blood donations and units of blood donated, some changes in hematological parameters are observed among long-term high-frequency platelet donors. Monitoring and health education should be strengthened to ensure the safety and quality of blood donors.
作者
严仲文
林栋
王梨花
叶群弟
尹柳云
曾琪
黄志森
YAN Zhongwen;LIN Dong;WANG Lihua;YE Qundi;YIN Liuyun;ZENG Qi;HUANG Zhisen(Dongguan Central Blood Station,Dongguan 523000,China)
出处
《中国输血杂志》
CAS
2022年第12期1216-1220,共5页
Chinese Journal of Blood Transfusion
