摘要
目的:分析对原发性高血压患者应用卡托普利联合吲哒帕胺治疗的效果。方法:选取2019年8月-2021年2月新疆维吾尔自治区干部疗养院收治的144例原发性高血压患者作为研究对象,根据就诊的先后顺序分为参照组和治疗组,各72例。参照组给予卡托普利进行治疗,治疗组在参照组基础上给予吲哒帕胺进行治疗。比较两组患者治疗效果、血压水平、血清内皮素1(ET-1)、一氧化氮(NO)、白细胞介素6(IL-6)水平及不良反应发生情况。结果:治疗组治疗总有效率高于参照组,差异有统计学意义(P<0.05)。治疗前,两组舒张压、收缩压水平比较,差异无统计学意义(P>0.05);治疗后,两组舒张压、收缩压水平均低于治疗前,且治疗组低于参照组,差异有统计学意义(P<0.05)。治疗前,两组血清ET-1、NO、IL-6水平比较,差异无统计学意义(P>0.05);治疗后,两组血清ET-1、IL-6水平低于治疗前,且治疗组低于参照组,差异有统计学意义(P<0.05);治疗后,两组血清NO水平高于治疗前,且治疗组高于参照组,差异有统计学意义(P<0.05)。治疗组不良反应发生率低于参照组,差异有统计学意义(P<0.05)。结论:原发性高血压患者应用卡托普利联合吲达帕胺治疗的效果显著,有利于促进血压稳定,对提高治疗效果以及减少不良反应均具有重要作用。
Objective:To analyze the effect of applying captopril combined with indapamide in patients with essential hypertension.Methods:144 patients with essential hypertension admitted to the Xinjiang Uygur Autonomous Region Cadre Sanatorium from August 2019 to February 2021 were selected as study subjects.According to the order of consultation,they were divided into the reference group and the treatment group,with 72 cases each.The reference group was treated with captopril,and the treatment group was treated with indapamide on the basis of the reference group.The treatment effect,blood pressure level,serum endothelin 1(ET-1),nitric oxide(NO),interleukin 6(IL-6)level and the occurrence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the treatment group was higher than that in the reference group,and the difference was statistically significant(P<0.05).Before treatment,the diastolic and systolic blood pressure levels of the two groups were compared,and the differences were not statistically significant(P>0.05);after treatment,the diastolic and systolic blood pressure levels of the two groups were lower than those before treatment,and the treatment group was lower than the reference group,and the differences were statistically significant(P<0.05).Before treatment,serum ET-1,NO and IL-6 levels in both groups were compared,and the differences were not statistically significant(P>0.05);after treatment,serum ET-1 and IL-6levels in both groups were lower than before treatment,and the treatment group was lower than the reference group,and the differences were statistically significant(P<0.05);after treatment,serum NO levels in both groups were higher than before treatment,and the treatment group was higher than the reference group,and the differences were statistically significant(P<0.05).The incidence of adverse reactions in the treatment group was lower than that in the reference group,and the difference was statistically significant(P<0.05).Conclusion:The combination
作者
刘家岩
Liu Jia-yan(Xinjiang Uygur Autonomous Region Cadre Sanatorium,Urumqi 830000,Xinjiang,China)
出处
《中国社区医师》
2022年第35期36-38,共3页
Chinese Community Doctors
