摘要
目的探讨大骨窗开颅联合甲基强的松龙治疗脑挫伤对预后的影响。方法选取2019年4月至2020年9月于吉林市人民医院治疗的86例脑挫伤患者作为研究对象,随机分为观察组与对照组,各43例。对照组行大骨窗开颅手术,观察组采用大骨窗开颅联合甲基强的松龙治疗,比较两组治疗效果及治疗前后格拉斯哥昏迷评分量表(GCS)评分、日常生活能力量表(ADL)评分、肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β),治疗后颅内压变化情况。结果观察组治疗有效率为88.4%,高于对照组的69.8%(P<0.05);观察组治疗后颅内压低于对照组(P<0.05),GCS评分及ADL评分高于对照组(P<0.05);治疗后观察组TNF-α及IL-1β水平低于对照组(P<0.05)。结论大骨窗开颅联合甲基强的松龙治疗脑挫伤能明显提升治疗效果,降低患者颅压,减少重残率及死亡率,减轻炎症刺激作用,对改善患者预后,促进脑功能恢复具有重要意义,应用价值高。
Objective To explore the prognosis effect of large bone window craniotomy combined with methyl prednisone on brain contusion.Methods 86 patients with brain contusion who were treated in Jilin People's Hospital from April 2019 to September 2020 were selected as the research objects,and randomly divided into the observation group and the control group,43 patients in each group.The control group was treated with large bone window craniotomy,and the observation group was treated with large bone window craniotomy combined with methylprednisolone.The therapeutic effect,Glasgow coma score(GCS),ability of daily living scale(ADL)score,Tumor necrosis factor-α(TNF-α),Interleukin-1β(IL-1β)between the two groups before and after,changes of intracranial pressure after treatment were compared.Results The effective rate of the observation group was 88.4%,which was higher than that of the control group 69.8%(P<0.05);After treatment,the intracranial pressure in the observation group was lower than that in the control group(P<0.05),and the GCS score and ADL score were higher than those in the control group(P<0.05);TNF-αand IL-1βin observation group after treatment was lower than that of the control group(P<0.05).Conclusion The treatment of brain contusion by large bone window craniotomy combined with methylprednisolone can significantly improve the treatment effect,reduce patient cranial pressure,reduce heavy residual rate and mortality,reduce inflammatory stimulation effect,It is of great significance to improve patient prognosis and promote the recovery of brain function,and has high application value.
作者
高强
GAO Qiang(Neurosurgery Department of Jilin Municipal People's Hospital,Jilin 132002,China)
出处
《中国药物经济学》
2022年第11期112-114,121,共4页
China Journal of Pharmaceutical Economics
关键词
大骨窗开颅
甲基强的松龙
脑挫伤
预后
Large bone window craniotomy
Methylprednisolone
Brain contusion
Prognosis
