摘要
目的 探讨肝胃不和型胃溃疡患者采用疏肝和胃汤联合兰索拉唑治疗对临床疗效、胃肠激素及血清炎症因子水平的影响。方法 选取2019年10月-2021年12月英德市中医院收治的共计98例肝胃不和型胃溃疡患者,根据随机摸球法分成对照组(49例)和观察组(49例)。对照组采用兰索拉唑治疗,观察组采用疏肝和胃汤联合兰索拉唑治疗。治疗6周后,对两组的临床疗效、中医证候评分、胃肠激素水平、血清炎症因子水平及不良反应进行比较。结果 治疗后,观察组总有效率(95.92%)高于对照组(81.63%,P<0.05);两组中医证候评分均较治疗前下降(P<0.05),且观察组低于对照组(P<0.01);两组胃动素(MTL)水平均较治疗前升高,胃泌素(GAS)水平均较治疗前降低,差异具有统计学意义(P<0.05),且观察组MTL水平高于对照组、GAS水平低于对照组,差异具有统计学意义(P<0.01);两组C反应蛋白(CRP)、白细胞介素-6(IL-6)水平均较治疗前降低(P<0.05),且观察组CRP、IL-6水平均低于对照组(P<0.01);观察组不良反应发生率(4.08%)低于对照组(16.33%,P<0.05)。结论 疏肝和胃汤联合兰索拉唑应用于肝胃不和型胃溃疡患者治疗中,可提高临床疗效,缓解患者临床症状,改善其胃肠激素和血清炎症因子水平,并减少不良反应的发生。
Objective To investigate the effects of Shugan Hewei Decoction combined with lansoprazole on clinical efficacy, gastrointestinal hormones, serum inflammatory factors in gastric ulcer patients with liver-stomach disharmony. Methods A total of 98 gastric ulcer patients with liver-stomach disharmony in Yingde Hospital of Traditional Chinese Medicine from October 2019 to December 2021 were selected. They were divided into a control group(49 cases) and an observation group(49 cases) according to the random ball-taking method. The control group was treated with lansoprazole, while the observation group was treated with Shugan Hewei Decoction combined with lansoprazole. After 6 weeks of treatment, the clinical efficacy, traditional Chinese medicine(TCM) syndrome score, levels of gastrointestinal hormones and serum inflammatory factors and adverse reactions of the two groups were compared. Results After treatment, the total effective rate of the observation group(95.92%) was higher than that(81.63%) of the control group(P < 0.05). Compared with the conditions before treatment, the TCM syndrome score and levels of gastrin(GAS), C-reactive protein(CRP) and interleukin-6(IL-6) of the two groups were decreased(all P < 0.05), while the motilin(MTL) level was increased(P < 0.05), with the observation group having more decrease or increase than the control group(P < 0.01) The incidence of adverse reactions in the observation group was 4.08% lower than 16.33% in the control group(P < 0.05). Conclusion Shugan Hewei Decoction combined with lansoprazole improved the clinical efficacy, relieved clinical symptoms, up regulated levels of gastrointestinal hormones and serum inflammatory factors and reduced the occurrence of adverse reactions in the treatment of gastric ulcer patients with liver-stomach disharmony.
作者
梁景露
邱志鸿
张国勇
LIANG Jinglu;QIU Zhihong;ZHANG Guoyong(Department of Spleen,Stomach and Kidney Diseases,Yingde Hospital of Traditional Chinese Medicine,Yingde 513000,China)
出处
《基层中医药》
2022年第10期29-34,共6页
Basic Traditional Chinese Medicine
关键词
胃溃疡
肝胃不和型
疏肝和胃汤
兰索拉唑
临床疗效
胃肠激素
C反应蛋白
白细胞介素-6
gastric ulcer
liver-stomach disharmony
Shugan Hewei Decoction
lansoprazole
clinical efficacy
gastrointestinal hormone
C-reactive protein
interleukin-6
