摘要
目的Corin是一种可将心房利钠肽前体(pro-ANP)切割成更小的生物活性分子心房利钠肽的跨膜丝氨酸蛋白酶,参与高血压、心脏肥大的病理生理过程。本研究旨在探讨Corin基因多态性与钠钾饮食干预后血压反应性之间的关系。方法本课题组2004年从中国陕西宝鸡7个村庄的124个家庭中招募514名参与者进行慢性盐负荷试验干预,包括3 d基线期、7 d低盐饮食、7 d高盐饮食和7 d高盐补钾饮食干预。选取15个Corin基因单核苷酸多态性(SNP)位点进行相关性分析。结果Corin SNP位点rs12509275与低盐期舒张压反应性显著相关,而rs3749584与低盐期脉压差反应性相关。SNP rs3749584、rs10517195与高盐期脉压差反应性相关。此外,rs17654278与高盐补钾期收缩压反应性相关;rs2271037与高盐补钾期舒张压反应性显著相关。rs4695253、rs12509275、rs2351783、rs36090894与高盐补钾期脉压差反应性相关。结论Corin基因多态性与血压钠钾反应性密切相关,提示Corin基因可能参与血压盐敏感性及钾敏感性的形成。
Objective Corin,a transmembrane serine protease that can cleave atrial natriuretic peptide precursor(pro-ANP)into atrial natriuretic peptide with smaller bioactive molecules,participates in the pathophysiological process of hypertension and cardiac hypertrophy.The purpose of this study was to explore the relationship of Corin gene variation with blood pressure responses to sodium and potassium dietary interventions.Methods In2004,we recruited 514 participants from124 families in7 villages of Baoji,Shaanxi Province,China.All the subjects received a3-day normal diet,a7-day low-salt diet,a7-day high-salt diet,and finally a7-day high-salt and potassium supplementation.Fifteen single nucleotide polymorphisms(SNPs)of Corin gene were selected for final analysis.Results SNPs rs12509275 were significantly associated with diastolic blood pressure(DBP)response to low-salt diet,while rs3749584 was associated with pulse pressure(PP)response to low-salt diet.SNP rs3749584 and rs10517195 were significantly associated with PP response to high-salt diet.In addition,rs17654278 were significantly associated with systolic blood pressure(SBP)response to high-salt and potassium supplementation,rs2271037 was significantly correlated with DBP responses to high-salt and potassium supplementation,and rs4695253,rs12509275,rs2351783,rs36090894 were significantly associated with PP response to high-salt and potassium supplementation.Conclusion Corin gene polymorphisms were associated with blood pressure response to sodium and potassium,suggesting that Corin gene may be involved in pathophysiological process of salt sensitivity and potassium sensitivity.
作者
王兰
牛泽家馨
郭艳杰
刘乃溶
姚艳妮
杨贝贝
王佳馨
李闯
刘盼盼
杨长娥
杜鸣飞
胡桂霖
张玺
王丹
张晓玉
褚超
廖月圆
马琼
王科科
贾昊
孙月
郭统帅
高卫华
牟建军
汪洋
WANG Lan;NIU Zejiaxin;GUO Yanjie;LIU Nairong;YAO Yanni;YANG Beibei;WANG Jiaxin;LI Chuang;LIU Panpan;YANG Chang’e;DU Mingfei;HU Guilin;ZHANG Xi;WANG Dan;ZHANG Xiaoyu;CHU Chao;LIAO Yueyuan;MA Qiong;WANG Keke;JIA Hao;SUN Yue;GUO Tongshuai;GAO Weihua;MU Jianjun;WANG Yang(Department of Cardiovascular Medicine,Xi’an International Medical Center Hospital,Xi’an 710100;Department of Cardiovascular Medicine,The First Affiliated Hospital of Xi’an Jiaotong University,Xi’an 710061;Department of Cardiovascular Medicine,Northwest Women’s and Children’s Hospital,Xi’an 710003;Department of Cardiovascular Medicine,Xi’an No.1 Hospital,Xi’an 710002;Global Health Institute,School of Public Health of Xi’an Jiaotong University Health Science Center,Xi’an 710061,China)
出处
《西安交通大学学报（医学版）》
CAS
CSCD
北大核心
2023年第1期22-29,共8页
Journal of Xi’an Jiaotong University（Medical Sciences）
基金
国家自然科学基金资助项目(No.81600327,No.81870319,No.82070437)
陕西省自然科学基金项目(No.2021JM-257,No.2021JM-588)
西安交通大学第一附属医院院基金(No.2019QN-06,No.2021ZXY-14)
西安交通大学第一附属医院临床研究项目(No.XJTU1AF-CRF-2019-004,No.XJTU1AF2021CRF-021)。
关键词
Corin基因
基因多态性
血压
盐
钾
Corin
genetic polymorphism
blood pressure
salt
potassium
