摘要
目的 探讨地尔硫䓬联合美托洛尔治疗冠心病不稳定型心绞痛的效果。方法 选择2020年2月至2021年2月我院诊治的80例冠心病不稳定型心绞痛患者作为研究对象,将其随机分为对照组(40例,美托洛尔)与观察组(40例,地尔硫䓬联合美托洛尔)。比较两组的治疗效果。结果 观察组的治疗总有效率高于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的左室射血分数高于对照组,左室收缩末期内径、左室缩短分数小于对照组(P<0.05)。治疗后,观察组的组织型纤溶酶原激活物(t-PA)、高密度脂蛋白胆固醇(HDL-C)水平高于对照组,纤溶酶原激活剂抑制物-1(PAI-1)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)水平低于对照组(P<0.05)。结论 地尔硫䓬联合美托洛尔治疗冠心病不稳定型心绞痛的效果显著,值得临床推广与应用。
Objective To investigate the effect of diltiazem combined with metoprolol in treatment of unstable angina pectoris of coronary heart disease. Methods From February 2020 to February 2021, 80 patients with unstable angina pectoris of coronary heart disease diagnosed and treated in our hospital were selected as the research objects. The patients were randomly divided into control group(40 cases, metoprolol) and observation group(40 cases, diltiazem combined with metoprolol). The therapeutic effects of the two groups were compared. Results The total effective rate of treatment in the observation group was higher than that in the control group, and the difference was statistically significant(P<0.05). After treatment, the left ventricular ejection fraction in the observation group was higher than that in the control group, the left ventricular end systolic diameter and left ventricular shortening fraction were less than those in the control group(P<0.05).After treatment, the levels of tissue type plasminogen activator(t-PA) and high-density lipoprotein cholesterol(HDL-C) in the observation group were higher than those in the control group, and the levels of plasminogen activator inhibitor-1(PAI-1), triglycerides(TG) and low-density lipoprotein cholesterol(LDL-C) were lower than those in the control group(P <0.05). Conclusion Diltiazem combined with metoprolol in the treatment of unstable angina pectoris of coronary heart disease has remarkable effect, which is worthy of clinical promotion and application.
作者
王建发
胡春阳
WANG Jianfa;HU Chunyang(No.2 Cardiovascular Medicine Department,the Third Affiliated Hospital of Xinxiang Medical University,Xinxiang 453003,China)
出处
《临床医学研究与实践》
2023年第2期33-35,共3页
Clinical Research and Practice
关键词
冠心病
不稳定型心绞痛
地尔硫䓬
美托洛尔
coronary heart disease
unstable angina pectoris
diltiazem
metoprolol
