摘要
目的探讨血浆脂联素(APN)对慢性心力衰竭(CHF)的临床诊断价值。方法纳入2018年5月—2019年5月在安徽省立医院确诊CHF的患者48例为CHF组及40例健康志愿者为对照组。比较2组血浆APN和氨基末端脑钠肽前体(NT-proBNP)水平,获取CHF组左室射血分数(LVEF),分析CHF组血浆APN与NT-proBNP、LVEF的相关性。根据美国纽约心脏病协会(NYHA)心功能分级对CHF患者分组,比较不同亚组间血浆APN、NT-proBNP及LVEF。采集CHF组治疗前及治疗后3个月、6个月血浆APN、NT-proBNP及LVEF,分析APN对CHF的诊断价值。结果CHF组年龄为45~91(60.98±13.98)岁,男性34例,女性14例;对照组年龄为51~93(57.88±13.76)岁,男性28例,女性12例。CHF组血浆APN、NT-proBNP分别为(23.08±9.39)μg/mL、5455.00(1256.00,8552.25)pg/mL,高于对照组[(12.06±3.28)μg/mL、55.50(32.00,78.50)pg/mL],差异有统计学意义(均P<0.05)。Pearson线性相关分析显示,CHF组血浆APN与NT-proBNP呈正相关,与LVEF呈负相关。APN、NT-proBNP随着心功能等级增加而升高,LVEF却明显降低。规范化心衰治疗后,血浆APN、NT-proBNP随着时间延长显著降低,LVEF却显著升高。结论CHF患者血浆APN与NT-proBNP水平呈正相关关系,与LVEF呈负相关关系,与NYHA心功能分级具有一致性,对CHF临床诊断具有一定的预测价值。
Objective To investigate the clinical value of plasma adiponectin(APN)in the diagnosis of chronic heart failure(CHF).Methods A total of 48 patients with CHF diagnosed in Anhui Provincial Hospital from May 2018 to May 2019 were included as CHF group,and 40 healthy volunteers were included as control group.The levels of plasma APN and NT-proBNP in the two groups were compared,the left ventricular ejection fraction(LVEF)in CHF group was obtained,and the correlation between plasma APN,NT-proBNP and LVEF in CHF group was analyzed.CHF patients were divided into groups by cardiac function classification of New York Heart Association(NYHA),and plasma APN,NT-proBNP and LVEF were compared between subgroups.Plasma APN,NT-proBNP and LVEF were collected before and 3 and 6 months after treatment in CHF group,and the diagnostic value of APN in CHF was preliminarily analyzed.Results In the CHF group,the age was 45-91(60.98±13.98)years,with 34 males and 14 females.In the control group,the age was 51-93(57.88±13.76)years,with 28 males and 12 females.The plasma APN and NT-proBNP in the CHF group were(23.08±9.39)μg/mL,5455.00(1256.00,8552.25)pg/mL,respectively,which were higher than those in the control group[(12.06±3.28)μg/mL and 55.50(32.00,78.50)pg/mL],the differences were statistically significant(all P<0.05).Pearson linear relationship analysis showed that the plasma APN was positively correlated with NT-pro BNP and negatively correlated with LVEF in the CHF group.The APN and NT-proBNP increased significantly with the increase of cardiac function grade,but LVEF decreased significantly.During the follow-up,the plasma APN and NT-proBNP decreased significantly with the improvement of the disease,but LVEF increased significantly.Conclusion The plasma APN is positively correlated with NT-proBNP and negatively correlated with LVEF in patients with CHF,which is consistent with NYHA cardiac function grade.It has certain predictive value for clinical diagnosis of CHF.
作者
陈东
冯俊
苏浩
张静
CHEN Dong;FENG Jun;SU Hao;ZHANG Jing(Department of Cardiology,the Second People's Hospital of Hefei(Hefei Hospital Affiliated to Anhui Medical University),Hefei,Anhui 230011,China;不详)
出处
《中华全科医学》
2022年第12期2059-2062,共4页
Chinese Journal of General Practice
基金
安徽省重点研究与开发计划(第一批)(202104j07020058)
安徽医科大学校科研基金项目(2020xkj073)
蚌埠医学院自然科学基金重点项目(2020byzd297)。
关键词
慢性心力衰竭
脂联素
B型氨基端利钠肽原
Chronic heart failure
Adiponectin
B type amino terminal natriuretic peptide
