摘要
颞下颌关节盘穿孔是颞下颌关节紊乱病(Temporomandibular disorders,TMD)中的严重结构紊乱类型之一,主要临床表现为疼痛、关节杂音和下颌运动障碍。目前的临床治疗手段预后欠佳,难以恢复关节盘正常解剖形态及功能,而组织工程技术的发展,使关节盘再生成为可能。研究发现,将间充质干细胞接种在具有一定强度的可生物降解支架上,在生长因子的刺激下可向纤维软骨分化,分泌胶原纤维和糖胺聚糖,最终支架被新生组织取代,关节盘实现再生。本文对近年来组织工程技术在关节盘再生方面的研究进展进行综述。
Temporomandibular joint disc perforation is one of the severe structural disorder in temporomandibular disorders(TMD).The main clinical manifestations are pain,sound and mandibular dyskinesias.At present,the prognosis of clinical treatment is poor,and it is difficult to restore the normal anatomical morphology and function of the articular disc.The development of tissue engineering technology has made it possible to regenerate the articular disc.It has been found that by seeding mesenchymal stem cells on a strong biodegradable scaffold,fibrocartilage differentiation is achieved under the stimulation of growth factors,and collagen fibers and glycosaminoglycans are secreted.Eventually,the scaffold is replaced by healthy tissue and the joint disc is regenerated.In this paper,the research progress of tissue engineering technology in articular disc regeneration was reviewed.
作者
向超丽
俞律峰
XIANG Chaoli;YU Lyufeng(Department of Stomatology,Shanghai Jiao Tong University Affiliated Sixth People's Hospital,Shanghai 200233,China)
出处
《组织工程与重建外科》
CAS
2022年第6期516-523,共8页
Journal of Tissue Engineering and Reconstructive Surgery
关键词
颞下颌关节紊乱病
关节盘穿孔
组织再生
组织工程
Temporomandibular disorders
Articular disc perforation
Tissue regeneration
Tissue engineering
