摘要
目的比较加巴喷丁与帕罗西汀治疗躯体形式障碍(SFD)患者疼痛、疲劳和失眠的效果。方法选取医院2018年7月至2020年12月收治的SFD患者78例,按随机数字表法分为加巴喷丁组(37例)和帕罗西汀组(39例)。两组患者均给予简短的认知行为治疗,并分别接受加巴喷丁0.3 g/d或帕罗西汀20 mg/d,均治疗12周。结果与治疗前比较,两组治疗结束时和治疗后3个月的症状自评量表-90(SCL-90)、医学结局研究疼痛量表(MOS-PM)、疲劳量表-14(FS-14)总分及各因子评分,以及睡眠障碍指数(SPI)均显著降低(P<0.05);加巴喷丁组和帕罗西汀组治疗结束时整体印象改变量表(GIC)评分分别为[2(1.0,3.0)]分和[2(1.5,3.0)]分(Z=0.737,P=0.461),治疗有效率相当(89.19%比84.62%,χ^(2)=0.063,P=0.802);治疗期间加巴喷丁组和帕罗西汀组不良反应发生率相当(24.32%比25.64%,χ^(2)=0.023,P=0.879)。结论在联合简短认知行为治疗背景下,加巴喷丁与帕罗西汀用于缓解SFD患者的疼痛、疲劳和失眠的有效性和安全性相当。
Objective To compare the effects of gabapentin and paroxetine in the treatment of pain,fatigue and insomnia in patients with somatoform disorders(SFD).Methods A total of 78 patients with SFD admitted to the hospital from July 2018 to December 2020 were selected and divided into the gabapentin group(37 cases)and the paroxetine group(39 cases)by the random number table method.The patients in the two groups were given the abbreviated cognitive behavioral therapy.The patients in the gabapentin group were treated with 0.3 g/d of gabapentin,while the patients in the paroxetine group were treated with 20 mg/d of paroxetine.Both groups were treated for 12 weeks.Results Compared with those before treatment,the total scores of Symptom Checklist-90(SCL-90),Medical Outcomes Study Pain Measurement(MOS-PM),Fatigue Scale-14(FS-14),the score of each factor of the above scales and the sleep problems index(SPI)in the gabapentin group and the paroxetine group at the end of treatment and the third month after the treatment decreased significantly(P<0.05).At the end of treatment,the Global Impression of Change(GIC)scores in the gabapentin group and the paroxetine group were[2(1.0,3.0)]points and[2(1.5,3.0)]points respectively(Z=0.737,P=0.461),and the treatment efficacy in the gabapentin group was similar to that in the paroxetine group(89.19%vs.84.62%,χ^(2)=0.063,P=0.802).During the treatment,the incidence of adverse reactions in the gabapentin group was similar to that in the paroxetine group(24.32%vs.25.64%,χ^(2)=0.023,P=0.879).Conclusion On the basis of abbreviated cognitive behavioral therapy,the efficacy and safety of gabapentin were similar to those of paroxetine in relieving pain,fatigue and insomnia in patients with SFD.
作者
史继红
岳阳
SHI Jihong;YUE Yang(Jining No.1 People's Hospital,Jining,Shandong,China 272011)
出处
《中国药业》
CAS
2023年第1期86-90,共5页
China Pharmaceuticals
基金
山东省医药卫生科技发展计划项目[2017WS148]。
关键词
躯体形式障碍
疼痛
疲劳
失眠
加巴喷丁
帕罗西汀
认知行为治疗
somatoform disorders
pain
fatigue
insomnia
gabapentin
paroxetine
cognitive behavioral therapy
