摘要
目的了解胆囊癌类器官研究的进展与当前面临的挑战并探讨可能的应对策略。方法对近年来国内外关于胆囊癌类器官研究的相关文献进行综述。结果胆囊癌类器官研究处于起步阶段,主要由手术切除的胆囊癌组织构建而来,目前利用胆囊癌类器官对胆囊癌的发病机制、药物筛选等的研究已取得一定进展。结论对胆囊癌类器官的研究能加深对胆囊癌的认识,有助于加快对胆囊癌诊疗方案的更新,但目前面临模型构建成功率低等挑战,消化系统其他肿瘤类器官的研究所取得的经验可以借鉴。
Objective To summarize the progress and challenges in the research of gallbladder cancer organoid,and explore the possible solution strategies.Method The literature relevant to the researches of gallbladder cancer organoid at home and abroad in recent years was reviewed.Results The research of gallbladder cancer organoid was in its infancy.The gallbladder cancer organoid was mainly constructed from surgically resected gallbladder cancer tissues.Now the research of gallbladder cancer organoid had made some progress,such as on the pathogenesis and drug screening of gallbladder cancer.Conclusions The study on gallbladder cancer organoid can further understand the gallbladder cancer and help to speed up the update of diagnosis and treatment plan.However,the model of gallbladder cancer organoid is facing the challenges such as low construction success rate.The experience gained from organoids research in other diseases is worthy of reference.
作者
叶宝龙
丁凯
嵇武
YE Baolong;DING Kai;JI Wu(The First College of Clinical Medicine,Southern Medical University,Guangzhou 510515,P.R.China;Department of General Surgery,General Hospital of Eastern Theater Command,Nanjing 210002,P.R.China)
出处
《中国普外基础与临床杂志》
CAS
2022年第12期1648-1652,共5页
Chinese Journal of Bases and Clinics In General Surgery
基金
江苏省第五期“333高层次人才培养工程”项目[项目编号:(2016)Ⅱ-463号]
江苏省科技项目社会发展面上项目(项目编号:BE2016746)。
关键词
胆囊癌
类器官
模型
个体化治疗
gallbladder cancer
organoid
model
individualized treatment
