摘要
目的了解四川省绵阳市安州区居民乙型肝炎病毒(HBV)新发感染的现状,分析其感染的影响因素,为乙肝防控措施的制定提供科学依据。方法纳入绵阳市安州区参加2013年“四川绵阳重大传染病综合防治示范研究”健康体检,且乙型肝炎表面抗原筛查结果为阴性的71418名居民作为研究对象。对其随访5年,2018年再次进行血清学检测。计算HBV新发感染率,用多因素Logistic回归分析HBV新发感染的影响因素。结果2018年71418名安州区居民的HBV新发感染率为1.61%。不同性别、年龄、职业、婚姻状况、吸烟情况、饮酒频率、居住地、乙肝家族史人群的HBV新发感染率不同(P<0.001),多因素Logistic回归分析显示,男性(OR=1.29,95%CI=1.12~1.48,P<0.001)、农民(OR=2.01,95%CI=1.39~2.90,P<0.001)、有乙肝家族史(OR=1.97,95%CI=1.44~2.70,P<0.001)为HBV新发感染的独立危险因素。结论绵阳市安州区居民的HBV新发感染率较高;男性、农民、有乙肝家族史者是HBV感染的高危人群,乙肝防控工作中需重点关注。
Objective To understand the status quo and analyze the influencing factors of new hepatitis B virus(HBV)infection in Anzhou district,Mianyang city,Sichuan province,so as to provide a scientific basis for the formulation of hepatitis B prevention and control measures.Methods This study enrolled 71418 residents of Anzhou District,Mianyang City,who participated in the physical examination of“Mianyang Comprehensive Prevention and Control Demonstration Study of Major Infectious Diseases”in 2013 and were tested negative for the hepatitis B surface antigen.The residents were followed for 5 years and underwent serological test again in 2018.The new infection rate of HBV was calculated and the influencing factors were analyzed by multivariate Logistic regression analysis.Results In 2018,the new infection rate of HBV among 71418 residents in Anzhou district was 1.61%.The new infection rate varied with the differences in gender,age,occupation,marital status,smoking status,drinking frequency,place of residence,family history of hepatitis B,and history of hepatitis B vaccination(P<0.001).Multivariate Logistic regression results showed that male(OR=1.29,95%CI=1.12-1.48,P<0.001),farmer(OR=2.01,95%CI=1.39-2.90,P<0.001),and family history of hepatitis B(OR=1.97,95%CI=1.44-2.70,P<0.001)were the independent risk factors for new HBV infection(P<0.001).Conclusions The new infection rate of HBV is high in Anzhou district of Mianyang city.Males,farmers,and those with family history of hepatitis B are high-risk groups of HBV infection.
作者
余雨珂
朱霞
陈梓萱
刘嘉琳
王琴
刘秀秀
袁萍
YU Yuke;ZHU Xia;CHEN Zixuan;LIU Jialin;WANG Qin;LIU Xiuxiu;YUAN Ping(Department of Epidemiology and Health Statistics,West China School of Public Health and West China Fourth Hospital,Sichuan University,Chengdu 610041 China;Center for Infectious Diseases,West China Hospital of Sichuan University,Chengdu 610041,China)
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
2022年第6期996-1003,共8页
Acta Academiae Medicinae Sinicae
基金
“十三五”国家科技重大专项(2018ZX10715003)。
关键词
乙型肝炎病毒
新发感染
影响因素
hepatitis B virus
new infection
influencing factor
