摘要
目的探讨血必净注射液联合内镜逆行性胰胆管造影术(ERCP)治疗急性胆源性胰腺炎的有效性及分析患者术后并发症。方法选取2020年7月~2022年7月我院住院治疗的急性胆源性胰腺炎患者57例,对照组(n=28)患者在入院后72小时内实施ERCP治疗,观察组(n=29)患者在对照组治疗的基础上联合血必净注射液100ml Tid治疗1周。此外,两组患者均给予禁食补液等对症的支持疗法。并比较观察组与对照组治疗在显效性,术前术后凝血功能,炎症水平以及并发症的出现等。结果果两组患者在治疗前基本资料比较未见差异,但经过相应的治疗后,观察组的显效性明显高于对照组(P=0.039);且观察组的平均住院时间(P<0.001),腹痛缓解时间(P=0.020),体温恢复正常时间(P<0.001)较对照组显著降低;在炎症反应方面,治疗后观察组的CRP(P=0.018)、WBC(P=0.041)、PAMY(P=0.013)均显著低于对照组,表明联合血必净治疗后,患者的炎症反应得到改善。此外,在凝血功能方面,经过治疗后观察组的APTT(P=0.017)、PT(P=0.026)、TT(P=0.003)水平均显著低于对照组,FIB水平均显著高于对照组(P<0.001)。在术后并发症统计方面,实验组患者术后出现出血、穿孔、感染例数分别为:2、0、1例;对照组出现出血、穿孔、感染例数分别为:1、0、1例,两组间比较无统计学差异(P>0.05)。结论ERCP联合血必净注射液联合较单纯ERCP治疗具有更高的显效性,可以减少住院时间,并减轻炎症反应,使患者凝血功能趋于正常,且无更高的术后并发症风险。
Objective To explore the efficacy of Xuebijing injection combined with endoscopic retrograde cholangiopancreatography(ERCP)in the treatment of acute biliary pancreatitis and analyse the postoperative complications.Methods 57 patients with acute biliary pancreatitis hospitalized in our hospital from July 2020 to July 2022 were selected.Patients in the control group(n=28)were treated with ERCP within 72 hours after admission,while patients in the observation group(n=29)were treated with Xuebijing injection 10Oml Tid for I week on the basis of the treatment in the control group.In addition,the patients in both groups were given symptomatic supportive therapy such as fasting and fluid replacement.Meanwhile,we compared the effectiveness of treatment,preoperative and postoperative coagulation function,inflammation level and complications between the observation group and the control group.Results There was no dfference in the basic data between the two groups before treatment,but afer corresponding treatment,the effectiveness of the observation group was significantly higher than that of the control group(P=0.039);The average hospitalization time(P<0.001),abdominal pain relief time(P=0.020)and temperature recovery time(P<0.001)in the observation group were significantly lower than those in the control group;In terms of inflammatory reaction,the CRP(P=0.018),WBC(P=0.041)and PAMY(P=0.O13)of the observation group were significantly lower than those of the control group after treatment,indicating that the inflammatory reaction of the patients was improved after the combination of Xuebijing.In addition,regarding coagulation function,after treatment,the levels of APTT(P=0.017),Pt(P=0.026)and TT(P=0.003)in the observation group were significantly lower than those in the control group,and the FIB levels were significantly higher than those in the control group(P<0.001).With regard to postoperative complications,the number of bleeding,perforation and infection in the experimental group were 2,O and 1 respectively;The number of
作者
孙学虎
张剑林
王兴宇
SUN Xue-hu;ZHANG Jian-lin;WANG Xing-yu(The First Hospital of Anhui Medical University,Hefei 230022,China)
出处
《肝胆外科杂志》
2022年第5期356-360,共5页
Journal of Hepatobiliary Surgery
关键词
急性胆源性胰腺炎
血必净注射液
内镜逆行性胰胆管造影
疗效
并发症
acute biliary pancreatitis
xuebijing injection
endoscopic retrograde cholangiopancreatography
efficacy
complications
