摘要
目的 系统评价养心氏片联合常规西药治疗冠心病(冠状动脉粥样硬化性心脏病)心绞痛患者的有效性。方法 检索中国知网、万方数据库、维普中文科技期刊数据库、PubMed,收集养心氏片联合常规西药(观察组)对比常规西药(对照组)治疗冠心病心绞痛的临床随机对照试验,检索时间为建库至2022年8月,采用Review Manager 5.3软件进行Meta分析。结果 最终纳入23篇文献,包括2 160例患者。Meta分析结果显示,观察组整体疗效(比值比=3.58,95%置信区间:2.53~5.06,Z=7.21,P<0.001)、心绞痛症状疗效(比值比=4.87,95%置信区间:3.35~7.08,Z=8.27,P<0.001)、心电图疗效(比值比=3.34,95%置信区间:2.44~4.56,Z=7.56,P<0.001)均优于对照组。观察组治疗后N末端B型脑钠肽前体、高敏C反应蛋白水平均低于对照组,一氧化氮水平高于对照组(均P<0.001)。结论 养心氏片联合常规西药治疗冠心病心绞痛患者,可提高整体疗效,改善临床症状。
Objective To evaluate the clinical efficacy of Yangxinshi tablets combined with routine western medicine on coronary atherosclerotic heart disease complicated with angina pectoris. Methods Clinical randomized controlled trials were retrieved form China National Knowledge Infrastructure, Wanfang Database, VIP China Science and Technology Journal Database and PubMed from the databases inception to August 2022. The trails aimed to compare the effect on coronary atherosclerotic heart disease complicated with angina pectoris between Yangxinshi tablets combined with routine western medicine(observation group) and routine western medicine(control group). Review Manager 5.3 software was used for the Meta-analysis. Results Totally 23 literatures were finally enrolled, including 2 160 patients. Meta-analysis showed that the total efficacy(odds ratio=3.58, 95% confidence interval: 2.53-5.06, Z=7.21, P<0.001), efficacy of angina pectoris symptoms(odds ratio=4.87, 95% confidence interval: 3.35-7.08, Z=8.27, P<0.001), and efficacy of electrocardiogram(odds ratio=3.34, 95% confidence interval: 2.44-4.56, Z=7.56, P<0.001) in the observation group were better than those in the control group. After treatment, levels of N-terminal pro-brain natriuretic peptide and high sensitivity C-reactive protein in the observation group were lower than those in the control group, and the level of nitric oxide in the observation group was higher than that in the control group(all P<0.001). Conclusion For patients of coronary atherosclerotic heart disease complicated with angina pectoris, Yangxinshi tablets combined with routine western medicine can improve the total efficacy and clinical symptoms.
作者
张赫怡
邢文龙
刘红旭
连妍洁
谭玉培
Zhang Heyi;Xing Wenlong;Liu Hongxu;Lian Yanjie;Tan Yupei(Department of Cardiovascular Medicine,Beijing Hospital of Traditional Chinese Medicine,Capital Medical University,Beijing 100010,China)
出处
《中国医药》
2022年第12期1858-1863,共6页
China Medicine
基金
国家中医药管理局中医药循证能力建设项目(2019XZZX-XXG001)
北京市属医院科研培育计划项目(Pz2021019)
北京市医院管理局重点医学专业发展计划(ZYLX201817)。
