摘要
Ranunculales,comprising of 7families that are rich in medicinal species frequently utilized by traditional medicine and ethnomedicine,represents a treasure chest of biodiversity and chemodiversity.The phylogenetically related species often have similar chemical profile,which makes them often possess similar therapeutic spectrum.Thishas been validatedby both ethnomedicinal experiences and pharmacological investigations.This paper summarizes molecular phylogeny,chemical constituents,and therapeutic applications of Ranunculales,i.e.,a pharmacophylogeny study of this representative medicinal order.The phytochemistryl metabolome,ethnomedicine and bioactivity/pharmacology data are incorporated within the phylogenetic framework of Ranunculales.The most studied compounds of this order include benzylisoquinoline alkaloid,flavonoid,terpenoid,saponin and lignan,etc.Bisbenzylisoquinolinealkaloids are especially abundant in Berberidaceae and Menispermaceae.The most frequent ethnomedicinal uses are arthritis,heat-clearing and detoxification,carbuncle-abscess and sore-toxin.The most studied bioactivities are anticancer/cytotoxic,antimicrobial,and anti-inflammatory activities,etc.The pharmacophylogeny analysis,integrated with both traditional and modern medicinal uses,agrees with the molecular phylogeny based on chloroplast and nuclear DNA sequences,in which Ranunculales is divided into Ranunculaceae,Berberidaceae,Menispermaceae,Lardizabalaceae,Circaeasteraceae,Papaveraceae,and Eupteleaceaefamilies.Chemical constituents and therapeutic efficacy of each taxonomic group are reviewed and the underlying connection between phylogeny,chemodiversityand clinical uses is revealed,which facilitate the conservation and sustainable utilization of Ranunculales pharmaceutical resources,as well as developing novel plant-based pharmacotherapy.
基金
Supported by the National Science and Technology Fundamental Resources Investigation Program of China(No.2018FY100700)
CAMS Innovation Fund for Medical Sciences(No.CIFMS 2021-12M-1-032)。
