摘要
Metastasis is the primary cause of HCC-related death.Neutrophils can activate the antitumor immune response and promote tumor cell clearance.However,most studies show that neutrophils support tumor progression and metastasis.The accumulation of neutrophils contributes to HCC progression and is associated with poor prognosis.1 Metabolic reprogramming is one of the significant hallmarks of cancers,and immune cells in the tumor microenvironment(TME)undergo complex metabolic alterations.
基金
supported by the National Nature and Sci-ence Foundation of China grants(No.82070601)
Outstanding Youth Project of Anhui Natural Science Foun-dation(No.1808085J11)
the Fundamental Research Funds for the Central Universities(No.WK9110000012).
