摘要
目的 分析≥60岁感染新冠病毒奥密克戎变异株确诊病例临床重型/危重型影响因素。方法 收集上海市2022年4月6日-6月12日某定点医院≥60岁感染新冠病毒奥密克戎变异株确诊病例的临床资料,根据病情程度分为轻型组、普通型组和重型/危重型组。采用logistics回归分析性别、年龄、新冠病毒疫苗接种剂次及基础疾病对重型/危重型病例的影响。结果 共纳入625例患者,其中轻型组455例,普通型组125例,重型/危重型组45例。60~69岁组重型/危重型病例占2.99%(7/234),70~79岁占7.34%(13/177),80~89岁占9.03%(13/144),≥90岁占17.14%(12/70);完成3、2、1剂次疫苗接种及未接种重型/危重型病例分别为2.33%(1/43),1.35%(1/74),6.98%(3/43),未接种8.60%(40/465),随年龄增大和疫苗接种剂数减少,重型/危重型病例的比例均逐渐升高,有明显的线性趋势(χ^(2)_(趋势)=28.288,P=0.004;χ^(2)_(趋势)=10.201,P=0.001)。多因素logistics回归分析显示,年龄(OR=1.606,95%CI=1.177~2.192)和糖尿病(OR=1.916,95%CI=1.030~3.565)是重型/危重型病例的危险因素。结论 高龄和患糖尿病是≥60岁感染新冠病毒奥密克戎变异株重型/危重型病例的危险因素,接种新冠病毒疫苗可有效降低重型/危重型病例的发生风险。
Objective To analyze influence factors of severe/critical conditions among elderly patients( ≥ 60 years)infected with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) Omicron variant. Methods Medical records of all elderly patients(≥ 60 years) with SARS-CoV-2 Omicron variant infection during April 6 – June 12, 2022 were extracted from a designated hospital for coronavirus disease 2019(COVID-19) in Shanghai city and the patients were assigned into different severity groups according to their clinical conditions. Univariate and multivariate logistic regression analysis were adopted in analysis on factors associated with clinical severity in the patents. Results Of the 625 patients included in the study, 455, 125, and 45 were mild, common, and severe/critical cases. In the patients, the proportion of severe/critical cases increased significantly by age, with the proportions of 2.99%(7/234), 7.34%(13/177), 9.03%(13/144),and 17.14%(12/70) for the patients aged 60 – 69, 70 – 79, 80 – 89, ≥ 90 years(χ^(2)_(trend) = 8.288, P = 0.004);the proportion also significantly increased inversely with the dose number of COVID-19 vaccination, with the proportions of 2.33%(1/43),1.35%(1/74), 6.98%(3/43), and 8.60%(40/465) for the patients having 3, 2, 1, and zero dose vaccine, respectively(χ^(2)_(trend) =10.201, P = 0.001). The results of multivariate logistic regression analysis showed that at older age(odds ratio [OR] = 1.606,95% confidence interval [95% CI]: 1.177 – 2.192) and suffering from diabetes(OR = 1.916, 95% CI: 1.030 – 3.565) were independent risk factors for severe/critical conditions. Conclusion For SARS-CoV-2 Omicron variant infected patients over60 years old, advanced age and having diabetes are risk factors for severe/critical conditions and vaccination could effectively reduce that risk.
作者
王凤
孟胜喜
王佳丽
袁菁
梁芳
邹锋
高清歌
蒋鹏
邹龑
王兵
WANG Feng;MENG Sheng-xi;WANG Jia-li(Shanghai Sixth People′s Hospital,Shanghai 200032,China)
出处
《中国公共卫生》
CAS
CSCD
北大核心
2022年第9期1108-1112,共5页
Chinese Journal of Public Health
基金
上海市第六人民医院院内新冠专项课题(ynxg202218)。
