摘要
目的分析血清白细胞介素(IL)-33水平与变应性鼻炎(AR)患者T淋巴细胞亚群水平的相关性。方法选取2018年4月至2020年10月该院收治的97例AR患者作为AR组。另选择同期来该院进行体检且无AR家族史及相关临床症状、体征的健康者100例作为对照组。对照组于体检当日、AR组于入院24 h内检测血清IL-33及T淋巴细胞亚群(CD3^(+)、CD4^(+)、CD8^(+))水平,同时分析AR患者血清IL-33与T淋巴细胞亚群的关系,并评价血清IL-33水平对AR的诊断价值。结果与对照组相比,AR组IL-33、CD8^(+)水平明显升高,而CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平则明显降低,差异均有统计学意义(P<0.05);Pearson相关分析发现,AR患者血清IL-33水平与CD8^(+)水平呈正相关(P<0.01),而与CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平均呈负相关(P<0.01);绘制受试者工作特征(ROC)曲线,结果发现血清IL-33诊断AR的曲线下面积为0.841(95%CI:0.738~0.945)。以62.50μg/L作为预测的临界值,灵敏度和特异度分别为88.64%、90.80%。结论AR患者血清IL-33水平较健康人明显升高,且与AR患者T淋巴细胞亚群的紊乱密切相关,因此,监测AR患者血清IL-33水平变化趋势对预测AR发病具有一定临床意义。
Objective To analyze the correlation between serum interleukin-33(IL-33)level and T lymphocyte subsets levels in the patients with allergic rhinitis(AR).Methods Ninety-seven patients with AR admitted to this hospital from April 2018 to October 2020 were selected as the AR group.In addition,100 healthy people without AR family history and related clinical symptoms and signs undergoing physical examination in this hospital in the same period were selected as the control group.The levels of serum IL-33 and levels of T lymphocytes subsets(CD3^(+),CD4^(+),CD8^(+))were detected on the physical examination day in the control group and within 24 h after admission in the AR group.Then the relationship between serum IL-33 and T lymphocyte subsets was analyzed,and the value of serum IL-33 level in diagnosing AR was evaluated.Results Compared with the control group,the levels of IL-33 and CD8^(+)in the AR group were significantly increased,while the levels of CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)were significantly decreased,and the differences were statistically significant(P<0.05);the Pearson correlation analysis found that the serum IL-33 level in the patients with AR was positively correlated with CD8^(+)level(P<0.01),while negatively correlated with CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)levels(P<0.01);the receiver operating characteristic(ROC)curve was drawn,and the results showed that the area under the ROC curve of serum IL-33 in diagnosing AR was 0.841(95%CI:0.738-0.945).With 62.50μg/L as the critical value of prediction,the sensitivity and specificity were 88.64%and 90.80%,respectively.Conclusion The serum IL-33 level in AR patients is significantly increased compared with that in healthy people,moreover it is closely related to the disorder of T lymphocyte subsets in AR patients.Therefore,monitoring the change trend of serum IL-33 level in AR patients has certain clinical significance in predicting the onset of AR.
作者
温振雷
王红梅
邹良玉
李连贺
WEN Zhenlei;WANG Hongmei;ZOU Liangyu;LI Lianhe(Department of Otorhinolaryngology Head and Neck Surgery,Chaoyang Municipal Central Hospital,Chaoyang,Liaoning 122000,China)
出处
《检验医学与临床》
CAS
2023年第1期41-44,共4页
Laboratory Medicine and Clinic
