摘要
目的探讨血清涎液化糖链抗原-6(KL-6)联合改良临床-影像-病理诊断(CRP)评分对间质性肺疾病(ILD)严重程度及预后的评估价值。方法以2020年7月至2022年12月该院收治的30例ILD患者为观察组,按ILD活动情况分为急性加重期(AE)组18例及稳定期(S)组12例;按治疗后转归情况分为预后良好组21例及预后不良组9例。另选择同期在该院体检的30例健康者作为对照组。比较各组血清KL-6水平及改良CRP评分,采用受试者工作特征(ROC)曲线分析血清KL-6联合改良CRP评分预测ILD病情严重程度的价值,同时分析对症治疗前后患者血清KL-6水平变化。结果观察组血清KL-6水平及改良CRP评分高于对照组,差异均有统计学意义(P<0.05);AE组血清KL-6水平及改良CRP评分高于S组,差异均有统计学意义(P<0.05);ROC曲线分析结果显示,血清KL-6及改良CRP评分联合预测ILD病情严重程度的曲线下面积(AUC)为0.935,此时灵敏度、特异度分别为77.78%、100.00%;对症治疗前后,预后不良组的血清KL-6水平高于预后良好组,差异均有统计学意义(P<0.05),治疗后预后良好组血清KL-6有明显下降,与治疗前比较差异有统计学意义(P<0.05),预后不良组血清KL-6水平稍见上升,但差异无统计学意义(P>0.05)。结论血清KL-6联合改良CRP评分可准确评估ILD病情严重程度,且血清KL-6水平在一定程度上还可反映ILD预后。
Objective To investigate the value of serum salivary liquefied carbohydrate antigen-6(KL-6)combined with modified clinical-radio-pathological diagnosis(CRP)score in evaluating the severity and prognosis of interstitial lung disease(ILD).Methods Thirty patients with ILD admitted and treated in this hospital from July 2020 to December 2022 served as the observation group and divided into the acute exacerbation stage(AE)group(18 cases)and stable stage(S)group(12 cases)according to the ILD activity situation.The patients were divided into the good prognosis group(21 cases)and poor prognosis group(9 cases)according to the outcome after treatment.Contemporaneous 30 healthy subjects undergoing physical examination served as the control group.The KL-6 levels and modified CRP scores were compared among various groups.The receiver operating characteristic(ROC)curve was used to analyze the value of KL-6 combined with modified CRP score in predicting the severity of ILD,meanwhile the changes of KL-6 levels before and after symptomatic treatment were analyzed.Results The serum KL-6 level and CRP score in the observation group were higher than those in the control group,and the difference was statistically significant(P<0.05).The serum KL-6 level and modified CRP score in the AE group were higher than those in the S group,and the difference was statistically significant(P<0.05).The ROC curve analysis results showed that the area under the curve(AUC)of serum KL-6 level combined with modified CRP score in predicting the ILD severity was 0.935,the sensitivity and specificity were 77.78%and 100.00%respectively;the serum KL-6 level before and after symptomatic treatment in the poor prognosis group was higher than that in the good prognosis group,and the difference was statistically significant(P<0.05).The serum KL-6 level after treatment in the good prognosis group was significantly decreased,which showed statistical difference compared with before treatment(P<0.05),the serum KL-6 level in the poor prognosis group was slightly incr
作者
钟钿
ZHONG Dian(Department of Respiration,Pingxiang Municipal People′s Hospital,Pingxiang,Jiangxi 337000,China)
出处
《检验医学与临床》
CAS
2023年第1期9-13,共5页
Laboratory Medicine and Clinic
基金
江西省卫生健康委员会科技计划项目(2202140560)。
关键词
间质性肺疾病
涎液化糖链抗原-6
改良临床-影像-病理诊断评分
interstitial lung disease
salivary liquefied carbohydrate antigen-6
clinical-radio-pathological diagnosis
prognosis
