摘要
瘢痕疙瘩是一种以大量胶原及细胞外基质沉积为特征的纤维增生性疾病, 目前治疗方法很多, 但复发率较高。近年来, 越来越多的研究表明多肽在防治瘢痕疙瘩方面有着巨大的潜力, 可以通过多种机制抑制过度纤维化、降低胶原表达、减轻胶原沉积、促进细胞外基质重塑, 达到治疗瘢痕疙瘩的目的。该文对多肽类物质在瘢痕疙瘩中的作用及机制的研究进展进行了综述, 以为相关研究提供借鉴。
Keloid is a type of skin fibroproliferative disease,characterized by excessive deposition of collagen in the extracellular matrix.There are many therapies for treating keloids now.However,the outcome of keloids treatment is still unsatisfied due to high recurrence rate.In recent years,polypeptides have shown great potential for preventing and treating keloid.These polypeptides are derived from cytokines,hormones and in vivo protehydrolysis.Polypeptides may inhibit the activation of fibroblasts,reduce the deposition of collagen and other extracellular matrix through multiple mechanisms.The article reviews current research progress on the roles of polypeptides and underlying mechanisms in keloid and provides reference for relevant research.
作者
张熠宁
邹继军
Zhang Yining;Zou Jijun(Department of Burn&Plastic Surgery,Children’s Hospital of Nanjing Medical University,Nanjing 210008,China)
出处
《中华整形外科杂志》
CSCD
2022年第10期1176-1180,共5页
Chinese Journal of Plastic Surgery
