摘要
目的探讨外周血血小板/淋巴细胞比值(PLR)、术前中性粒细胞/淋巴细胞比值(NLR)、淋巴细胞/单核细胞比值(LMR)在宫颈癌的预后的临床意义。方法选取2010年6月至2015年6月于广东省人民医院接受宫颈癌根治术治疗的270例宫颈癌ⅠA2~ⅡA期患者作为研究对象,收集患者临床资料和随访资料,采用COX多因素分析相关指标与疾病预后的相关性,并绘制受试者工作特征(ROC)曲线评估各指标对疾病预后的预测能力。结果肿瘤直径、国际妇产科联盟(FIGO)分期、淋巴结转移情况、间质浸润深度及鳞状细胞癌相关抗原(SCC-Ag)、PLR、NLR及LMR水平与宫颈癌患者术后总生存期(OS)及无进展生存期(PFS)显著相关(P<0.05)。COX多因素分析结果显示,PLR、NLR及LMR值偏高是宫颈癌患者术后OS的独立危险因素(P<0.05);分期较晚、PLR、NLR及LMR值偏高是宫颈癌患者术后PFS的独立危险因素(P<0.05)。ROC曲线结果显示,PLR、NLR、LMR水平预测宫颈癌患者术后预后的ROC曲线下面积分别为0.549、0.608、0.687。结论PLR、NLR、LMR可预测宫颈癌患者预后情况,对预后的评估价值从高到低依次为LMR、NLR、PLR。
Objective To explore the clinical significance of peripheral blood platelet to lymphocyte ratio(PLR),preoperative neutral to lymphocyte ratio(NLR)and monocyte to lymphocyte ratio(LMR)in the prognosis of cervical cancer.Methods A total of 270 patients with cervical cancer stagesⅠA2-ⅡA who received radical surgery for cervical cancer in Guangdong Provincial People′s Hospital from June 2010 to June 2015 were selected as the research subjects.The clinical and follow-up data of the patients were collected.COX multivariate analysis was used to analyze the relevant indicators and disease prognosis.The correlation of each index,and the receiver operating curve(ROC)was drawn to evaluate the predictive ability of each index on disease prognosis.Results Tumor diameter,international federation of gynecology and obstetrics(FIGO)stage,lymph node metastasis,depth of stromal invasion,squamous cell carcinoma-associated antigen(SCC-Ag),PLR,NLR and LMR levels were significantly correlated with postoperative overall survival(OS)and progression-free survival(PFS)in patients with cervical cancer(P<0.05).COX multivariate analysis showed that higher values of PLR,NLR and LMR were independent risk factors for postoperative OS in patients with cervical cancer(P<0.05);late stage,higher values of PLR,NLR and LMR were independent risk factors for postoperative PFS in patients with cervical cancer(P<0.05).ROC curve analysis showed that the areas under the ROC curve of PLR,NLR and LMR levels for predicting postoperative prognosis of patients with cervical cancer were 0.549,0.608,and 0.687,respectively.Conclusions PLR,NLR and LMR can predict the prognosis of patients with cervical cancer.The evaluation value of prognosis from high to low is LMR,NLR and PLR.
作者
欧丽滢
马俊楠
陈茵
周琛斐
OU Liying;MA Junnan;CHEN Yin;ZHOU Chenfei(Department of Obstetrics and Gynecology,GuangdongProvincial People′s Hospital′s Nanhai Hospital(the Second People′s Hospital of Nanhai),Foshan 528251,Guangdong,China;Departmentof Obstetrics and Gynecology,Guangdong Provincial Institute of Cardiovascular Diseases(Guangdong Provincial People′s Hospital),Guangzhou510000,Guangdong,China;Department of Obstetrics and Gynecology,Guangdong Provincial People′s Hospital(Guangdong Academy of MedicalSciences),Guangzhou 510000,Guangdong,China)
出处
《中国性科学》
2022年第12期76-80,共5页
Chinese Journal of Human Sexuality
基金
国家自然科学基金青年项目资助(81902621)。
