摘要
目的以糠酸莫米松鼻喷剂联合氯雷他定对小儿变应性鼻炎患儿进行治疗,观察实际疗效。方法对中山市南区医院2020年6月-2021年6月间接收的106例变应性鼻炎患儿进行随机分组,分为研究组(n=53)及对照组(n=53)。对照组采取氯雷他定治疗,研究组在此基础上采取糠酸莫米松鼻喷剂治疗,对两组总有效率、治疗前后IL-6、IL-17、IgE水平以及不良反应情况进行比较。结果研究组总有效率为94.34%,较对照组(75.47%)更高(P<0.05)。治疗后,两组IL-6、IL-17及IgE水平均有所下降,但研究组各项指标水平更低(P<0.05)。研究组不良反应发生率为11.32%,对照组为9.43%,两组比较无显著差异性(P>0.05)。结论糠酸莫米松鼻喷剂联合氯雷他定治疗小儿变应性鼻炎能够获得较为理想的效果,可有效控制炎症反应,进而缓解相关症状,不良反应较少,用药安全性较为理想。
Objective To investigate the clinical efficacy of mometasone furoate nasal spray combined with loratadine in the treatment of children with allergic rhinitis.Methods 106 children with allergic rhinitis received in our hospital from June 2020 to June 2021 were randomly divided into a study group(n=53)and a control group(n=53).The control group was treated with loratadine,and the study group was treated with mometasone furoate nasal spray on this basis.The total effective rate,IL6,IL-17,IgE levels and adverse reactions were compared between the two groups.Results The total effective rate of the study group was 94.34%,which was higher than that of the control group(75.47%)(P<0.05).After treatment,the levels of IL-6,IL-17 and IgE in the two groups decreased,but the levels of various indexes in the study group were lower(P<0.05).The incidence of adverse reactions in the study group was 11.32%,and that in the control group was 9.43%,there was no significant difference between the two groups(P>0.05).Conclusion Mometasone furoate nasal spray combined with loratadine in the treatment of children with allergic rhinitis can achieve ideal results,can effectively control the inflammatory reaction,and then relieve related symptoms,with fewer adverse reactions and ideal medication safety.
作者
陈家源
CHEN Jiayuan(Department of Otolaryngology,South District Hospital of Zhongshan City,Zhongshan,Guangdong,528455)
出处
《智慧健康》
2022年第29期90-93,共4页
Smart Healthcare
关键词
糠酸莫米松鼻喷剂
氯雷他定
小儿变应性鼻炎
炎性因子
Mometasone furoate nasal spray
Loratadine
pediatric allergic rhinitis
Inflammatory factors
