摘要
我国糖尿病患病率持续升高,胰岛素是治疗糖尿病的重要手段之一。目前胰岛素治疗仍面临起始和强化治疗延迟的挑战,导致患者血糖控制不佳。胰岛素治疗中潜在的低血糖风险、血糖变异性和治疗依从性等多方面的问题也是临床治疗的难点。与既往常用的胰岛素制剂相比,新型胰岛素类似物制剂具有作用时间延长、药效动力学/药代动力学更稳定等特点,在临床应用中可提升胰岛素治疗的安全性,改善血糖变异性,提高患者治疗意愿和依从性,为糖尿病患者安全、便捷、稳定控制血糖提供了良好的治疗选择。
The prevalence of diabetes mellitus in China is rising year by year.Insulin is one of the important treatment means.However,insulin therapy still faced with the challenges of delayed initiation and intensive treatment,resulting in poor clinical blood glucose control.The potential risks of hypoglycemia,glycemic variability,treatment compliance,and other problems in insulin therapy make difficulties in clinic.Compared with currently used insulin,new insulin analogues have characteristics of longer action time and more stable pharmacokinetic/pharmacokinetic features,and can improve the safety of insulin treatment,glycemic variability,and patients′treatment willingness and compliance in clinical application,thus provide good treatment options for safe,convenient,and stable control of blood glucose in diabetes patients.
作者
甄健存
Zhen Jiancun(Department of Pharmacy,Beijng Jishuitan Hospital,Beijing 100035,China)
出处
《药物不良反应杂志》
CSCD
2022年第11期561-563,共3页
Adverse Drug Reactions Journal
关键词
糖尿病
胰岛素
安全
胰岛素类似物
血糖变异性
治疗依从性
Diabetes mellitus
Insulin
Safty
Insulin analogues
Glycemic variability
Treatment compliance
