摘要
目的:研究癌胚抗原(carcinoembryonic antigen,CEA)联合空腹血糖(fasting plasma glucose,FPG)水平检测在评估晚期胃癌预后中的应用价值。方法:回顾性分析我院接受化疗的300例晚期胃癌患者的临床资料。收集患者化疗前的人口学资料、血液学指标、病理及影像学资料,并对患者2年生存期进行随访。使用ROC曲线确定CEA、FPG最佳临界值。采用Kaplan-Meier分析法比较不同分组间患者的生存曲线情况。使用多元COX风险回归模型分析CEA、FPG与患者预后的相关性。结果:CEA、FPG评估胃癌预后的最佳临界值分别为5.865 mg/mL、6.845 mmol/L。Log-rank检验显示CEA、FPG与患者总生存期(overall survival,OS)显著相关(CEA组:P=0.000;FPG组:P=0.000)。低CEA-低FPG组2年存活率为67.9%,低CEA-高FPG组为16.9%,高CEA-低FPG组为26.4%,高CEA-高FPG组为6.9%,各组存活率差异具有统计学意义(P=0.00)。COX回归分析显示性别、TNM分期、分化程度、CEA水平、FPG水平、吸烟史、是否手术是影响患者预后的危险因素(HR=0.717、HR=0.162、HR=0.591、HR=1.006、HR=1.097、HR=0.421、HR=2.504,P<0.05)。结论:联合检测CEA和FPG水平对评估晚期胃癌患者预后具有一定的临床价值。
Objective:To study the value of combined level detection of carcinoembryonic antigen(CEA)and fasting plasma glucose(FPG)in evaluating the prognosis of advanced gastric cancer.Methods:The clinical data of 300 patients with advanced gastric cancer who received chemotherapy in our hospital were analyzed retrospectively.The demographic,hematological,pathological and imaging data were collected before chemotherapy,and the 2-year survival time was followed up.The best critical value of CEA and FPG was determined by ROC curve.The survival curves of patients in different groups were compared by Kaplan-Meier analysis.Multivariate COX risk regression model was used to analyze the correlation between CEA,FPG and prognosis.Results:The best critical values for evaluating the prognosis of gastric cancer in CEA and FPG were 5.865 mg/mL and 6.845 mmol/L.Log-rank test showed that there was a significant correlation between CEA,FPG and overall survival(OS)(CEA group:P=0.000.FPG group:P=0.000).The 2-year survival rate was 67.9%in the low CEA and low FPG group,16.9%in the low CEA and high FPG group,26.4%in the high CEA and low FPG group,and 6.9%in the high CEA and high FPG group.The difference in survival rate among groups was statistically significant(P=0.00).COX regression analysis showed that gender,TNM stage,degree of differentiation,CEA level,FPG level,smoking history and operation were the risk factors affecting the prognosis of the patients(HR=0.717,HR=0.162,HR=0.591,HR=1.006,HR=1.097,HR=0.421,HR=2.504,P<0.05).Conclusion:The combined level detection of CEA and FPG has a certain clinical value in evaluating the prognosis of advanced gastric cancer patients.
作者
殷文博
王子安
YIN Wenbo;WANG Zian(Department of Oncology,the First Affiliated Hospital of Bengbu Medical College,Anhui Bengbu 233000,China)
出处
《现代肿瘤医学》
CAS
北大核心
2023年第2期282-286,共5页
Journal of Modern Oncology
基金
安徽省教育厅重点课题(编号:KJ2017A238)
蚌埠医学院研究生创新计划项目(编号:Byycxz20046)。
关键词
癌胚抗原
空腹血糖
晚期胃癌
预后
carcinoembryonic antigen
fasting plasma glucose
advanced gastric cancer
prognosis
