摘要
宫颈癌是最常见妇科恶性肿瘤之一,其发病率和导致的患者死亡率均居全球癌症第4位。目前已明确宫颈癌的发生、发展与高危型人乳头瘤病毒(HR-HPV)持续感染有关。环状RNA(circRNA)是一种新型内源性非编码RNA(ncRNA),与其他种类RNA相比,circRNA的3个主要特征为进化保守性、结构稳定性和组织特异性。不同种类circRNA在宫颈癌中异常表达,可通过调控其相应结合元件参与宫颈癌细胞增殖、迁移和侵袭等,从而在宫颈癌的发生、发展中发挥重要作用。笔者拟就circRNA的生物学功能及其在宫颈癌发病机制中作用的最新研究进行阐述,旨在为宫颈癌的诊疗提供新靶点。
Cervical cancer is one of the most common gynecological malignancies,and its morbidity and mortality both rank fourth in the world.It is now clear that the occurrence and development of cervical cancer are related to persistent infection with high risk-human papillomavirus(HR-HPV).Circular RNA(circRNA)is a new type of endogenous non-coding RNA(ncRNA),compared with other types of RNA,the three main characteristics of circRNA are evolutionary conservation,structural stability and tissue specificity.Different kinds of circRNA are abnormally expressed in cervical cancer and can participate in proliferation,migration and invasion of cervical cancer cells by regulating their corresponding binding elements,thereby playing an important role in the occurrence and development of cervical cancer.In this paper,the biological functions of circRNA and latest researches on its role of cervical cancer pathogenesis are reviewed,so as to provide a new target for the diagnosis and treatment of cervical cancer.
作者
卫怡妙
李亚芹
赵卫红
Wei Yimiao;Li Yaqin;Zhao Weihong(Department of Obstetrics and Gynecology,Second Hospital of Shanxi Medical University,Taiyuan 030001,Shanxi Province,China)
出处
《中华妇幼临床医学杂志（电子版）》
CAS
2022年第5期512-516,共5页
Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition)
基金
国家自然科学基金项目(81702583)
中国博士后科学基金项目(2019M651072)
山西省应用基础研究计划(201901D211506)。
