摘要
环状RNA(Circular RNA,circRNA)是一类共价闭合环状结构的内源性非编码RNA,广泛存在于哺乳动物细胞中,具有高度保守性、组织特异性、疾病特异性、时序特异性等特征。近年来,分子生物学技术和高通量核酸测序技术的广泛运用极大丰富了研究者对circRNA的了解,circRNA在糖尿病发生发展过程中的重要调节作用也被证实。目前糖尿病诊断及治疗多集中在血糖监测和管理层面,探寻新的诊断和治疗思路具有重要意义。已有文献表明,circRNA参与胰岛素合成分泌、胰岛β细胞程序性凋亡、胰岛素抵抗和胰岛炎症等过程,并有望成为糖尿病诊断的生物标志物以及新的治疗靶点。本综述系统地总结了circRNA在不同类型糖尿病发生、诊断以及治疗中的作用,以期为进一步了解糖尿病的发病机制及寻找治疗方法提供一些见解。
Circular RNA(circRNA),a class of endogenous non-coding RNA with covalently closed continuous loop structure,was revealed to be abundant in mammalian cells and characterized by highly conserved,tissue-specific,disease-specific and time-specific.With the wide application of molecular biology and high-throughput sequencing technology,the researchers′understanding of circRNA has been greatly enriched in recent years,and the important regulatory role of circRNA in the occurrence and development of diabetes has been also confirmed.Currently,the diagnosis and treatment of diabetes are mostly focused on blood glucose monitoring and management,and it is important to explore new diagnostic and therapeutic ideas.Furthermore,circRNA has been confirmed to be involved in the processes such as insulin biogenesis and secretion,programmed apoptosis of isletβcell,insulin resistance and islet inflammation,and was expected to be biomarker and therapeutic target of diabetes.The role of circRNA in the pathogenesis,diagnosis and treatment of different types of diabetes were systematically summarized in this review,in order to further understand the pathogenesis of diabetes and provide some ideas to find therapeutic approaches.
作者
陈家乐
刘建兴
刘悦
张方方
金亮
CHEN Jia-le;LIU Jian-xing;LIU Yue;ZHANG Fang-fang;JIN Liang(School of Life Science and Technology,China Pharmaceutical University,Nanjing 211198,China)
出处
《药物生物技术》
CAS
2022年第5期509-514,共6页
Pharmaceutical Biotechnology
基金
国家自然科学基金项目(No.82070801,No.82100858)。
