摘要
目的分析抗双链DNA(dsDNA)抗体测定阳性在自身免疫性疾病患者中的免疫学特征。方法回顾性分析168例自身免疫性疾病患者临床资料,其中,免疫印迹法检测抗dsDNA抗体阳性106例,阴性62例。比较抗dsDNA抗体阳性患者与阴性患者的一般资料、抗核抗体谱、实验室检测结果、临床特征。结果抗dsDNA抗体阳性患者平均年龄为(57.75±12.32)岁,高于抗dsDNA抗体阴性患者的(50.36±14.17)岁,差异有统计学意义(P<0.05)。抗dsDNA抗体阳性患者系统性红斑狼疮占比为35.85%,低于抗dsDNA抗体阴性患者的61.29%,差异有统计学意义(P<0.05)。抗dsDNA抗体阳性患者与阴性患者的性别及系统性硬化症、原发性干燥综合征、重叠综合征、未分化结缔占比比较差异无统计学意义(P>0.05)。抗dsDNA抗体阳性患者抗核抗体阳性、抗中性粒细胞胞浆抗体阳性、抗髓过氧化物酶抗体阳性、血清滴度≥1∶500占比分别为86.79%、70.20%、51.56%、92.45%,高于抗dsDNA抗体阴性患者的59.68%、22.73%、16.34%、77.42%,狼疮抗凝物质阳性占比33.96%低于抗dsDNA抗体阴性患者的61.29%,差异均有统计学意义(P<0.05)。抗dsDNA抗体阳性患者与阴性患者的抗SSA抗体阳性、抗SSB抗体阳性、抗风湿因子阳性占比比较,差异无统计学意义(P>0.05)。抗dsDNA抗体阳性患者的免疫球蛋白(Ig)G(12.05±5.14)g/L低于抗dsDNA抗体阴性患者的(14.32±7.42)g/L,差异有统计学意义(P<0.05)。抗dsDNA抗体阳性患者与阴性患者的白细胞、红细胞、血小板、IgA、IgM、C3、C4、血沉比较,差异无统计学意义(P>0.05)。抗dsDNA抗体阳性患者雷诺氏现象发生率43.40%、冠心病反应发生率33.96%,高于抗dsDNA抗体阴性患者的12.90%、16.13%,差异有统计学意义(P<0.05)。抗dsDNA抗体阳性患者与阴性患者的眼睑干结、手脚麻肿、肺纤维化、肝功能损害、肾蛋白溢出发生率比较,差异无统计学意义(P>0.05)。结论系统性红斑狼疮�
Objective To analyze the immunological characteristics of positive anti-double-stranded DNA(dsDNA)antibody assays in patients with autoimmune diseases.Methods The clinical data of 168 patients with autoimmune diseases were retrospectively analyzed,among which 106 patients were positive and 62 were negative for anti-dsDNA antibodies by immunoblotting.The general data,antinuclear antibody spectrum,laboratory test results,and clinical characteristics of patients with positive and negative anti-dsDNA antibodies were compared.Results The average age of patients with positive anti-dsDNA antibody was(57.75±12.32)years old,which was higher than(50.36±14.17)years old of patients with negative anti-dsDNA antibody,and the difference was statistically significant(P<0.05).The proportion of systemic lupus erythematosus in patients with positive anti-dsDNA antibody was 35.85%,which was lower than 61.29% in patients with negative anti-dsDNA antibody,and the difference was statistically significant(P<0.05).The gender,percentage of systemic sclerosis,primary sjogren’s syndrome,overlap syndrome,and undifferentiated connective were compared between patients with negative and positive anti-dsDNA antibody,and the differences were not statistically significant(P>0.05).The percentages of antinuclear antibody positivity,anti-neutrophil cytoplasmic antibody positivity,anti-myeloperoxidase antibody positivity,and serum titers≥1∶500 were 86.79%,70.20%,51.56%,and 92.45% in anti-dsDNA antibody positivity patients,which were higher than 59.68%,22.73%,16.34%,and 77.42% in anti-dsDNA antibody negative patients;the percentage of positive lupus anticoagulant substances in anti-dsDNA antibody-positive patients was 33.96%,which was lower than 61.29%in anti-dsDNA antibody-negative patients;all differences were all statistically significant(P<0.05).There was no statistically significant difference in the percentage of anti-SSA antibody positivity,anti-SSB antibody positivity,and anti-rheumatoid factor positivity between patients with positive
作者
徐超成
罗俭权
陶珊花
XU Chao-cheng;LUO Jian-quan;TAO Shan-hua(Department of Clinical Laboratory,Sihui People's Hospital,Sihui 526200,China)
出处
《中国实用医药》
2022年第26期96-99,共4页
China Practical Medicine
关键词
抗双链DNA抗体
自身免疫性疾病
临床表现特征
病程
Anti-double-stranded DNA antibodies
Autoimmune diseases
Clinical features
Disease course
