摘要
目的:探究自拟胃萎汤辅助治疗慢性萎缩性胃炎(CAG)患者的效果。方法:选取80例CAG患者,按照随机数字表法将其分成两组。A组接受自拟胃萎汤联合维酶素片治疗,B组接受维酶素片治疗。分析两组治疗总有效率、中医证候积分、全血高切黏度、血浆黏度、全血低切黏度、免疫球蛋白(IgA、IgM)、前列腺素E(PGE)、内皮素-1(ET-1)水平、不良反应。结果:A组治疗总有效率97.50%高于B组80.00%,差异有统计学意义(P<0.05);治疗3个月后,A组胃脘疼痛、反酸嗳气、大便不畅、胃脘胀满中医证候积分低于B组(P<0.05);A组IgA、IgM、PGE水平高于B组(P<0.05);A组全血高切黏度、血浆黏度、全血低切黏度、ET-1水平低于B组(P<0.05);两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论:自拟胃萎汤联合维酶素片治疗CAG可有效调节血液流变学指标和免疫功能,提高治疗效果。
Objective: To investigate the effect of self-made Weiwei decoction on the adjuvant treatment of patients with chronic atrophic gastritis(CAG). Methods: 80 patients with CAG were randomized into two groups, each with 40 cases. Group A received the treatment with self-made Weiwei decoction combined with vitacoenzyme tablets, while Group B were treated with vitacoenzyme tablets. Then, the total effective rate, TCM syndrome score, high shear viscosity of whole blood, plasma viscosity, low shear viscosity of whole blood, immunoglobulin(IgA), IgM, prostaglandin E(PGE), endothelin-1(ET-1)levels and the incidence of adverse reactions were compared between both groups. Results: The total effective rate of Group A was 97.50%, higher than 80.00% of Group B, and the differences were statistically significant(P<0.05);after 3 months of treatment, the TCM syndrome scores of epigastric pain, acid reflux and belching, obstructed defecation and epigastric fullness in Group A were lower than those in Group B(P< 0.05);the levels of IgA, IgM and PGEwere higher than those in Group B(P< 0.05);the levels of high shear viscosity of whole blood, plasma viscosity, low shear viscosity of whole blood and ET-1 were lower than those in Group B(P<0.05);and there was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05). Conclusion: The self-made Weiwei decoction combined with vitacoenzyme tablets in the treatment of CAG can effectively regulate hemorheological indexes, improve the immune function and treatment effect.
作者
赵银锋
辛丽娜
ZHAO Yinfeng;XIN Lina(Sanmenxia Hospital,Sanmenxia 472000,China)
出处
《华夏医学》
CAS
2022年第5期153-157,共5页
Acta Medicinae Sinica
关键词
慢性萎缩性胃炎
维酶素片
自拟胃萎汤
免疫功能
chronic atrophic gastritis(CAG)
vitacoenzyme tablets
self-made Weiwei decoction
immunity function
