摘要
目的:分析白介素细胞18(IL-18)、趋化细胞因子配体1(CCL-1)、降钙素原(PCT)在妊娠晚期B群链球菌(GBS)阳性孕妇血清中的表达及不良妊娠结局影响因素。方法:回顾性分析本院2019年10月-2020年10月收治的妊娠晚期孕妇132例临床资料,统计GBS阳性感染率,比较不同感染组IL-18、CCL-1、PCT血清水平及妊娠结局,多元logistic回归分析影响妊娠晚期GBS阳性孕妇不良妊娠结局的危险因素。结果:132例中GBS阳性感染63例,未感染69例。阳性组血清IL-18(91.55±17.29 pg/ml)、CCL-1(13.46±4.08 mmol/L)、PCT(0.72±0.19 ng/ml)及不良妊娠结局发生率(63.5%)均高于阴性组(68.27±11.23 pg/ml、9.51±3.58 mmol/L、0.41±0.15 ng/ml、27.5%),孕妇年龄≥35岁、有流产史、经产史、妊娠期糖尿病、妊娠期高血压疾病、流动人口、阴道pH>4.5、阴道微生态失调、IL-18>78 pg/ml、CCL-1>15 mmol/L、PCT>0.5 ng/ml占比均高于阴性组,正常分娩率(36.5%)低于阴性组(72.5%)(P<0.05);经非条件多因素logistic回归模型分析,年龄≥35岁、存在流产史、妊娠期糖尿病、妊娠期高血压疾病、流动人口、阴道pH>4.5、阴道微生态失调、IL-18>78 pg/ml、CCL-1>15 mmol/L、PCT>0.5 ng/ml均是影响妊娠晚期GBS阳性孕妇不良妊娠结局的危险因素(P<0.05)。结论:IL-18、CCL-1、PCT作为妊娠晚期GBS阳性产妇的监测,对临床上减少不良妊娠结局的发生具有重要意义。
Objective:To analyze the expression levels of interleukin 18(IL-18),chemotactic cytokine ligand 1(CCL-1),and procalcitonin(PCT)of pregnant women with positive group B streptococcus(GBS)during third trimester of pregnancy,and to study their influence on the adverse pregnancy outcomes of these women.Methods:The clinical data of 132 pregnant women during the third trimester from October 2019 to October 2020 was analyzed retrospectively.The GBS positive infection rate of the women was counted.The serum levels of IL-18,CCL-1,and PCT,and the pregnancy outcomes of were compared between the women with positive GBS(in group A)and the women with negative GBS(in group B).Multivariate Logistic regression was used to analyze the risk factors affecting the adverse pregnancy outcomes of the women in group A during the third trimester of pregnancy.Results:Among 132 women,there were 63 cases in group A and 69 cases in group B.The serum levels of IL-18(91.55±17.29 pg/ml),CCL-1(13.46±4.08 mmol/L),and PCT(0.72±0.19 ng/ml),and the incidence of adverse pregnancy outcomes(63.5%)of the women in group A were significantly higher than those(68.27±11.23 pg/ml,9.51±3.58 mmol/L,0.41±0.15 ng/ml,and 27.5%)of the women in group B.The percentages of the women aged over 35 years old,women with a history of miscarriage,women with a history of multiparity,women with gestational diabetes,women with gestational hypertension,floating population,women with vaginal pH>4.5,women with vaginal microecological disorders,women with the level of IL-18>78pg/ml,CCL-1>15mmol/L,or PCT>0.5ng/mL in group A were all significantly higher than those in group B(P<0.05).The normal delivery rate(36.5%)of the women in group A was significantly lower than that(72.5%)of the women in group B(P<0.05).The unconditional multivariate logistic regression model showed the the women aged over 35 years old,women with a history of miscarriage,women with a history of multiparity,women with gestational diabetes,women with gestational hypertension,floating population,women with va
作者
杨萱
陈芳蓉
周昌娜
YANG Xuan;CHEN Fangrong;ZHOU Changna(Dongfang People's Hospital,Hainan Province,572600)
出处
《中国计划生育学杂志》
2022年第12期2884-2888,共5页
Chinese Journal of Family Planning
基金
海南省卫生计生行业科研项目(19A200065)。
关键词
妊娠晚期
B群链球菌
白介素细胞18
趋化细胞因子配体1
降钙素原
不良妊娠结局
影响因素
The third trimester of pregnancy
Group B streptococcus
Interleukin 18
Chemotactic cytokine ligand 1
Procalcitonin
Adverse pregnancy outcomes
Influence factor
