摘要
Aim:Breast cancer is typically detected either during a screening examination or after a woman notices a lump.Breast cancers have different phenotypes depending on the presence/absence of an estrogen receptor(ER)and/or an epidermal growth factor(Her-2)receptor.The objective of the present investigation was to investigate growth inhibitory activity of methanol-,ethanol-,and water-extracts from papaya fruit and leaves on MDA-MB-231(ER-/Her-2-),MCF-7(ER+/Her-2-),SK-BR-3(ER-/Her-2+)and MDA-MB-361,AU565(ER+/Her-2+)breast cancer cells.Methods:The anti-oxidation potential of papaya extracts was determined by assessing their total polyphenol content,total flavonoid content and by assaying their anti-oxidation capacity.The effects on breast cancer cells proliferation were determined using a WST-1 assay.Results:The seeds and leaves contained higher anti-oxidation potential than that of the skin and pulp fractions.Our data indicate that methanol-and ethanol-extracts of papaya leaves,skin,pulp,and seeds have no effect on any of the breast cancer cell lines,whereas water-extract of leaves and seeds caused low to modest cytotoxic effects only on ER-negative breast cancer cell lines.Conclusion:Our data suggest that bioactive compound in papaya leaves can be potentially used to develop anti-cancer agents for ER-negative breast cancer.
