摘要
血管内皮细胞损伤、巨噬细胞吞噬脂质泡沫化以及平滑肌细胞的增殖和迁移是动脉粥样硬化的主要病理特征。线粒体是细胞的“ATP工厂”,高脂应激造成线粒体氧化磷酸化效率降低,ATP合成受阻,活性氧生成增加,脂质蓄积形成脂质核心。重要事件包括过氧化物酶体增殖物激活受体α和过氧化物酶体增殖物激活受体γ协同激活因子-1α表达降低,线粒体DNA生物合成减少,线粒体膜电位降低,ATP含量下降,活性氧累积。现探讨动脉粥样硬化病理发生过程中的线粒体功能与临床干预治疗,为动脉粥样硬化的靶向干预治疗提供思路。
The pathogenesis of atherosclerosis involves the injury of vascular endothelial cells,phagocytosis of macrophages to foam cells,and proliferation and migration of smooth muscle cells.Mitochondria are the“ATP factory”of cells.Hyperlipidemic stress reduces the oxidative phosphorylation efficiency of mitochondria,inhibits ATP synthesis,increases the production of reactive oxygen species,and accumulates lipids to form lipid cores.Important events include PPAR and PGC-1αexpression decreased,mitochondrial DNA biosynthesis decreased,mitochondrial membrane potential decreased,ATP content decreased,and reactive oxygen species accumulated.This paper aims to explore the mitochondrial function and clinical intervention in the pathogenesis of atherosclerosis,and provide ideas for targeted intervention therapy of atherosclerosis.
作者
王雪梅
王怡婷
曹莹
汪洁英
李婧
门可
WANG Xuemei;WANG Yiting;CAO Ying;WANG Jieying;LI Jing;MEN Ke(Department of Public Health,Xi’an Medical University,Xi’an 710000,Shaanxi,China;Key Laboratory of Ischemic Cardiovascular Disease in Shaanxi&Institute of Basic and Translational Medicine of Xi’an Medical University,Xi’an 710000,Shaanxi,China;Research Center for Medical Prevention and Control of Public Safety of Shaanxi Province,Xi’an 710000,Shaanxi,China)
出处
《心血管病学进展》
CAS
2022年第11期1016-1020,1049,共6页
Advances in Cardiovascular Diseases
基金
国家自然科学基金(81900408,81760083)
陕西省教育厅重点科学研究计划项目(20JS137)
陕西省自然科学基础研究计划项目(2021JQ-779)
陕西省教育厅公共应急项目(20JG027)
西安医学院博士科研项目(2020DOC08)
大学生创新创业训练计划项目(202111840001)。
