摘要
目的探讨婚姻状况对喉鳞状细胞癌(laryngeal squamous cell carcinoma,LSCC)患者生存结局的影响。方法从SEER数据库筛选2004年至2015年登记的LSCC患者的临床随访数据,根据婚姻状况分为已婚和未婚两组,采用1∶1倾向性匹配分析(propensity score matching,PSM)平衡混杂偏倚。在PSM前后均使用Kaplan-Meier方法绘制癌症5年总生存曲线和癌症5年特异性生存曲线,对不同婚姻状况下LSCC患者进行预后分析,并使用Log-rank方法进行检验;通过Cox比例风险模型对患者5年癌症特异性生存率进行单因素与多因素分析。结果本研究共纳入19042例患者,PSM匹配后样本量为14400例,匹配后Kaplan-Meier分析显示已婚组LSCC患者5年总生存率(57%vs.47%)、中位生存期(87个月vs.53个月)、5年癌症特异性生存率(69%vs.62%)均显著高于未婚组(P<0.05)。Cox比例风险模型显示未婚与LSCC患者预后不良显著相关,未婚可能是LSCC患者5年癌症特异性生存率低的危险因素[HR=1.35,95%CI(1.27,1.43),P<0.05]。结论已婚LSCC患者5年总生存率、5年癌症特异性生存率均显著高于未婚者,婚姻状况是LSCC患者的独立预后因素。
Objective To explore the impact of marital status on survival outcomes of patients diagnosed with laryngeal squamous cell carcinoma(LSCC).Method Clinical characteristics,basic personal information,and survival follow-up data of patients with LSCC registered from 2004 to 2015 were extracted from the SEER database.Patients were divided according to their marital status into married and unmarried groups.In order to balance the differences between groups,a 1:1 propensity matching analysis(PSM)was performed using the MatchIt package in R software.5-years overall survival(OS)curves and 5-years cancer-specific survival(CSS)curves were plotted before and after PSM using the Kaplan-Meier method,and the correlation between marital status and the prognosis of LSCC patients was analyzed and tested by the log-rank method.A univariate and multivariate analysis of patient CSS was then performed using the Cox proportional risk model.Results A total of 19,042 patients were included in this study.The sample size after PSM matching was 14,400.Kaplan-Meier analysis showed that the 5-year OS rate(57%vs.47%)and median OS survival time(87 months vs.53 months)and the 5-year CSS rate(69%vs.62%)of LSCC patients in the married group was higher than that in the unmarried group(P<0.05).Cox proportional risk model showed that unmarried status was significantly correlated with poor prognosis for LSCC patients.Unmarried status may be a risk factors for poor prognosis of CSS in LSCC patients[HR=1.35,95%CI(1.27,1.43),P<0.05].Conclusion The 5-years CSS and 5-years OS rates of LSCC patients in the married group were significantly higher than those in the unmarried group,marital status was an independent prognostic factor for LCSS patients.
作者
王高雅
朱思蓉
杨敏兰
明小平
杨修平
陈雄
Gao-Ya WANG;Si-Rong ZHU;Min-Lan YANG;Xiao-Ping MING;Xiu-Ping YANG;Xiong CHEN(Department of Otorhinolaryngology Head and Neck Surgery,Zhongnan Hospital of Wuhan University,Wuhan 430071,China;Department of Occupational and Environmental Health,School of Public Health,Wuhan University,Wuhan 430071,China)
出处
《医学新知》
CAS
2022年第6期424-433,共10页
New Medicine
基金
国家自然科学基金项目(82071033)。
关键词
喉鳞状细胞癌
预后因素
婚姻状况
生存分析
SEER数据库
Laryngeal squamous cell carcinoma
Prognostic factors
Marital status
Survival analysis
SEER database
