摘要
肥胖是由能量摄入和能量消耗长期失衡引起的脂肪过度堆积。近年来,全球肥胖人数持续上涨,肥胖已成为主要的公共健康问题。肥胖增加糖尿病、脂肪肝、心血管疾病、癌症等多种疾病的风险,导致患者生活质量及寿命下降,严重威胁人类健康。然而,肥胖发生发展机制复杂,干预肥胖的手段仍然有限。因此,需要深入了解肥胖发生发展的机制并提出干预策略。文章对肥胖的发生因素、干预策略、现有问题以及未来前景进行讨论。总而言之,肥胖治疗仍然面临巨大挑战,但新的减肥方式也给人们带来希望。
Obesity is characterized by the excess accumulation of fat caused by long-term imbalance between energy intake and expenditure.Obesity becomes a major public health problem with increasing prevalence worldwide.Obesity is the major risk factor for various diseases including diabetes,fatty liver,cardiovascular diseases and certain types of cancer,which cause serious health consequences and limits human healthspan and lifespan.Nonetheless,current therapeutic interventions are still lacking due to limited efficacy or potential adverse effects.Therefore,it is imperative to obtain deeper mechanistic understandings and novel intervention strategies for obesity.Here,we comprehensively discuss the leading causes,intervention ways,existing problems and future perspective for better understanding and treating obesity.Overall,although it is still a major challenge,promising ways for weight control are emerging.
作者
张彦康
张婷
李雨
马欣然
徐凌燕
ZHANG Yankang;ZHANG Ting;LI Yu;MA Xinran;XU Lingyan(Shanghai Key Laboratory of Regulatory Biology/School of Life Sciences,East China Normal University,Shanghai 200241,China)
出处
《自然杂志》
CAS
2022年第6期469-479,共11页
Chinese Journal of Nature
关键词
肥胖
代谢性疾病
脂肪组织
能量平衡
产热
obesity
metabolic disease
adipose tissue
energy homeostasis
thermogenesis
