摘要
睡眠剥夺(sleep deprivation,SD)已是全球性的公共卫生问题,其对人的身心健康产生深远的影响,扰乱机体各方面功能,其中对认知功能的损害尤为重要。虽然SD对认知功能的危害逐渐成为热点话题,但其相关机制尚不明确。文章通过免疫系统、氧化应激、突触可塑性、肠‑脑轴等多方面综述SD导致认知功能障碍的相关机制,分析多种肠道菌群代谢物的相关研究,为SD导致认知功能障碍机制的探索提供新的角度,为今后改善睡眠障碍提供一定启发。
Sleep deprivation(SD)appears common daily and has become a global public health problem.As a basic physiological need,sleep plays a vital role in the development and maintenance of individual physical and mental health,while SD may have various adverse effects on the body's normal physiological function.It is clear that SD can lead to cognitive impairment,such as slow response,decreased attention,impaired memory,and decreased executive function.Although sleep deprivation's negative effect on cognitive function has gradually become a hot topic,its related mechanism is unclear.This paper reviews the related studies of cognitive impairment caused by SD through the immune system,oxidative stress,synaptic plasticity,and gut‑brain axis and also analyzes the related studies of a variety of intestinal flora metabolites.Therefore,this provides a new perspective for exploring the mechanism of cognitive impairment caused by SD and provides some inspiration for the measures that can be taken to improve sleep disorders in the future.
作者
牟燕
徐晶
李娜
王强
Mou Yan;Xu Jing;Li Na;Wang Qiang(The Second Clinical Medical College of Shaanxi University of Chinese Medicine,Xianyang 712046,China;Department of Anesthesiolo-gy,the First Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710061,China;Department of Medicine,Xi'an Jiaotong University,Xi'an 710049,China)
出处
《国际麻醉学与复苏杂志》
CAS
2022年第10期1113-1116,共4页
International Journal of Anesthesiology and Resuscitation
基金
国家自然科学基金(81974540,81774113)。
关键词
睡眠剥夺
免疫系统
氧化应激
突触可塑性
肠道菌群代谢物
认知障碍
Sleep deprivation
Immune system
Oxidative stress
Synaptic plasticity
Intestinal flora metabolites
Cognitive disorder
