摘要
目的:分析生物重建与截肢手术对胫骨远端骨肿瘤患者预后的影响。方法:回顾性分析我院2015年1月-2019年12月收治的100例胫骨远端骨肿瘤患者临床资料,依据治疗方案分为生物重建组、截肢手术组各50例,生物重建组于保肢手术后行带血管蒂腓骨重建治疗,截肢手术组采取截肢手术治疗,对比两组患者肿瘤标志物指标(癌胚抗原、糖链抗原19-9、糖链抗原125、神经元特异性烯醇化酶)、生存质量评分(生理、心理、社会关系、环境)、MSTS评分、复发率差异。结果:术前两组患者肿瘤标志物指标、生存质量评分差异无统计学意义(P>0.05),术后肿瘤标志物指标均较本组术前显著下降、生存质量评分均较本组术前显著上升,差异有统计学意义(P<0.05),生物重建组术后肿瘤标志物指标与截肢手术组数值相当,差异无统计学意义(P>0.05),术后生存质量评分显著大于截肢手术组,差异有统计学意义(P<0.05);生物重建组MSTS评分大于截肢手术组、复发率高于截肢手术组,差异均有统计学意义(P<0.05)。结论:在胫骨远端骨肿瘤治疗中生物重建与截肢手术均能够取得理想的近期疗效,但生物重建更有助于改善患者生存质量及肢体功能,却也存在着复发风险高的不足。
Objective:To analyze the impact of biological reconstruction and amputation on the prognosis of patients with distal tibial bone tumors.Methods:The clinical data of 100 patients with distal tibial bone tumors admitted to our hospital from January 2015 to December 2019 were retrospectively analyzed.According to the treatment plan,they were divided into a biological reconstruction group and an amputation group with 50 cases each.The biological reconstruction group performed fibular reconstruction with vascular pedicle after limb salvage surgery,and the amputation group was treated with amputation.The tumor markers(carcinoembryonic antigen,carbohydrate antigen 19-9,carbohydrate antigen 125,neuron-specific enolization)were compared between the two groups.Differences in quality of life scores(physiological,psychological,social relations,environment),MSTS scores,recurrence rates were compared.Results:There was no significant difference in tumor markers and quality of life scores between the two groups of patients before operation(P>0.05).Postoperative tumor markers were significantly lower than preoperative tumor markers of this group,and the quality of life scores after operation were higher than those of this group before operation,the difference was statistically significant(P<0.05).The postoperative tumor markers in the biological reconstruction group were the same as those in the amputation group,but the difference was not statistically significant(P>0.05).The postoperative quality of life score was significantly greater than that of the amputation group,and the difference was statistically significant(P<0.05).The MSTS score of the biological reconstruction group was greater than that of the amputation group,and the recurrence rate was higher than that of the amputation group.The differences were statistically significant(P<0.05).Conclusion:Biological reconstruction and amputation can achieve ideal short-term effects in the treatment of bone tumors of the distal tibia.However,biological reconstruction is more help
作者
马秉正
衣静
彭国栋
MA Bingzheng;YI Jing;PENG Guodong(Department of Orthopaedics,Qingdao Municipal Hospital,Shandong Qingdao 266011,China)
出处
《现代肿瘤医学》
CAS
北大核心
2022年第24期4514-4517,共4页
Journal of Modern Oncology
关键词
胫骨远端骨肿瘤
生物重建
截肢手术
生存质量
复发率
distal tibial bone tumor
biological reconstruction
amputation
quality of life
recurrence rate
