摘要
目的观察布地奈德联合硫酸特布他林雾化吸入治疗慢性阻塞性肺疾病急性加重期(AECOPD)的临床效果。方法选取2020年4-12月湖北省安陆市普爱医院收治的AECOPD患者92例,以随机均等原则分为联合组和对照组,每组46例。对照组患者采取硫酸特布他林雾化吸入治疗,联合组患者接受布地奈德混悬液联合硫酸特布他林雾化吸入治疗,2组均治疗1周。比较2组患者的临床疗效、治疗前后肺功能指标、血清炎性因子水平及不良反应。结果联合组患者治疗总有效率为95.65%,高于对照组的82.61%(χ^(2)=4.039,P=0.044)。治疗1周后,2组患者第1秒用力呼气量(FEV 1)、最大呼气流量(PEF)、用力肺活量(FVC)均升高,且联合组高于对照组(P<0.05);2组患者血清降钙素原(PCT)、白介素-6(IL-6)及干扰素-γ(IFN-γ)均降低,且联合组低于对照组(P<0.05)。对照组与联合组患者不良反应总发生率比较差异无统计学意义(13.04%vs.15.21%,χ^(2)=0.090,P=0.765)。结论布地奈德联合硫酸特布他林雾化吸入治疗AECOPD可有效改善病情,改善肺功能和炎性因子,安全性高,值得推广。
Objective To observe the clinical effect of budesonide combined with terbutaline sulfate atomization in the treatment of acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods A total of 92 AECOPD patients admitted to Anlu Puai Hospital,Hubei Province from April to December in 2020 were randomly divided into combined group and control group,with 46 patients in each group.Control group was treated with atomization inhalation of terbutaline sulfate,and combined group was treated with budesonide suspension combined with atomization inhalation of terbutaline sulfate,both groups were treated for 1 week.The clinical efficacy,pulmonary function indexes,serum inflammatory factors and adverse reactions before and after treatment were compared between 2 groups.Results The total effective rate in combination group was 95.65%,which was higher than 82.61%in control group(χ^(2)=4.039,P=0.044).After 1 week of treatment,the forced expiratory volume in 1 second(FEV 1),maximum expiratory flow(PEF)and forced vital capacity(FVC)in 2 groups were increased,and combined group was higher than control group(P<0.05);The serum levels of procalcitonin(PCT),interleukin-6(IL-6)and interferon-γ(IFN-γ)in 2 groups decreased,and those in combined group were lower than those in control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the control group and the combined group(13.04%vs.15.21%,χ^(2)=0.090,P=0.765).Conclusion Budesonide combined with terbutaline sulfate atomization inhalation in the treatment of AECOPD can effectively improve the condition,improve lung function and inflammatory factors,with high safety and worthy of promotion.
作者
张光法
钟华
吴长圣
李威
高文
陈曦
ZHANG Guangfa;ZHONG Hua;WU Changsheng;LI Wei;GAO Wen;CHEN Xi(Department of Respiratory Medicine,Anlu Puai Hospital,Hubei Province,Anlu 432600,China)
出处
《临床合理用药杂志》
2022年第28期20-22,26,共4页
Chinese Journal of Clinical Rational Drug Use
基金
白求恩·医学科学研究基金资助项目(SC2186BS)。
关键词
慢性阻塞性肺疾病
急性加重期
布地奈德
硫酸特布他林
雾化吸入
临床疗效
肺功能
炎性因子
Chronic obstructive pulmonary disease,acute exacerbation
Budesonide
Terbutaline sulfate
Atomization inhalation
Clinical efficacy
Lung function
Inflammatory cytokines
