摘要
目的 观察宽胸利肺汤合三子养亲汤治疗痰浊壅肺型慢性阻塞性肺疾病急性加重期(AECOPD)的临床疗效及其对Toll样受体(TLRs)/核转录因子κB(NF-κB)信号通路的影响。方法 选取2020-2021年永州市中医医院收治的痰浊壅肺型AECOPD患者84例,采用随机数字表法分为对照组(n=42)和观察组(n=42)。对照组采用常规西医治疗,观察组给予宽胸利肺汤合三子养亲汤治疗。2组均治疗7 d。比较2组临床疗效,治疗前、治疗7 d后肺功能指标[用力肺活量(FVC)、第1秒用力呼气容积占预计值百分比(FEV%)及呼气峰流速占预计值百分比(PEF%)]、TLR4、NF-κB,不良反应。结果 观察组治疗总有效率为90.48%,高于对照组的71.43%(χ^(2)=3.977,P=0.046)。治疗7 d后,2组FVC、FEV%及PEF%均较治疗前升高,且观察组高于对照组(P<0.05)。治疗7 d后,2组血清TLR4、NF-κB水平均较治疗前降低,且观察组低于对照组(P<0.01)。2组不良反应总发生率比较,差异无统计学意义(P=1.000)。结论 宽胸利肺汤合三子养亲汤治疗痰浊壅肺型AECOPD的临床疗效确切,可有效改善患者肺功能,调控TLRs/NF-κB信号通路,且安全性较高。
Objective To observe clinical efficacy of Kuanxionglifei decoction and Sanziyangqin decoction in the treatment of acute exacerbation of chronic obstructive pulmonary disease(AECOPD) with phlegm dampness blocking lung type and its impact on TLRs/NF-κB signal pathway.Methods A total of 84 cases of patients with AECOPD with phlegm dampness blocking lung type were selected from 2020 to 2021 in Yongzhou Hospital of Traditional Chinese Medicine,which were divided into control group(n=42) and observation group (n=42) according to random number table method.The control group was treated with routine western medicine,while the observation group was treated with Kuanxionglifei decoction and Sanziyangqin decoction.Clinical efficacy,lung function indexes(FVC,FEV%,PEF%),TLR4,NF-κB before and after 7 days of treatment were compared between the two groups,and the incidence of adverse reactions were observed.Results The effective rate of the observation group was 90.48%,which was higher than 71.43%of the control group(χ^(2)=3.977,P=0.046).After 7 days of treatment,FVC,FEV%and PEF%in the two groups were higher than those before treatment,and the observation group were higher than those in the control group(P<0.05).After 7 days of treatment,the levels of serum TLR4 and NF-κB levels in the two groups were lower than those before treatment,and the observation group were lower than those in the control group (P<0.01).There was no significant difference in the total incidence of adverse reactions between the two groups(P=1.000).Conclusion Kuanxionglifei decoction and Sanziyangqin decoction have an exact clinical effect for AECOPD with phlegm dampness blocking lung type,which can effectively improve patients’lung function and regulate T TLRs/NF-κB signal pathway,and with high safety.
作者
肖启龙
曹康凯
XIAO Qilong;CAO Kangkai(Department of Internal Medicine 2,Yongzhou Hospital of Traditional Chinese Medicine,Yongzhou 425000,China)
出处
《临床合理用药杂志》
2022年第30期26-29,共4页
Chinese Journal of Clinical Rational Drug Use
基金
湖南省西学中骨干人才培训项目(湘中医药函[2020]40号)。
