摘要
目的分析多模态MRI成像对H3 K27M突变型弥漫性中线胶质瘤的诊断价值。方法收集经病理确诊的14例H3 K27M突变型弥漫性中线胶质瘤患者临床和影像学资料,分析总结MRI特征。结果14例中9例位于颅内,病灶呈长T_(1)稍长T_(2)信号,8例可见囊变,2例病灶内见出血,DWI显示实性部分弥散受限;5例发生于脊髓,呈长T_(1)、稍长T_(2)信号,增强扫描14例病灶以不均匀强化方式为主。结论H3 K27M突变型弥漫性中线胶质瘤磁共振表现具有一定的特征,对其术前准确诊断具有价值。
Objective To analyze the diagnostic value of multimodal MRI in H3 K27M mutant diffuse midline glioma(DMG).Methods The clinical and imaging data of 14 patients with H3 K27M mutant DMG confirmed by pathology were collected.The characteristics of MRI were analyzed and summarized.Results Among the 14 cases,9 were located intracranially,with long T_(1) and slightly long T_(2) signals,8 showed cystic change and 2 showed bleeding in the lesions.DWI showed limited diffusion in the solid portion.The other 5 cases occurred in the spinal cord and showed long T_(1) and slightly long T_(2) signals.All the cases showed inhomogeneous enhancement on enhancement scan.Conclusion The MRI finding of H3 K27M mutant DMG has certain characteristics,which are of value for its accurate preoperative diagnosis.
作者
李少朋
程传东
邓克学
王朋
邱俊
LI Shao-peng;CHENG Chuan-dong;DENG Ke-xue(Department of Radiology and Neurology,The First Affiliated Hospital of USTC,Division of Life Sciences and Medicine,University of Science and Technology of China,Hefei 230036,China)
出处
《临床神经外科杂志》
2022年第6期625-629,共5页
Journal of Clinical Neurosurgery
基金
安徽省自然科学基金项目(2108085MH296)。
