摘要
目的:明确经典名方实脾散方剂组成与应用,为其中医临床应用提供文献证据支撑,复方制剂的研发提供理论依据。方法:采用文献计量学方法,以“实脾散”及别名“实脾饮”为关键词,古籍文献通过中华医典数据库(V5.0)进行检索,现代研究文献通过国家知识基础设施数据库(CNKI)、中国生物医学文献数据库(CBM)、中国学术期刊数据库(CSPD)进行检索,检索时间均为建库至2020年2月。并根据纳入排除标准进行文献筛选。结果:收集了相关古籍数据89条,涉及中医古籍26本,其中宋代1本、元代1本、明代16本、清代8本;方剂组成与原文一致的共有19条,即由厚朴、白术、茯苓、木瓜、木香、干姜、附子、大腹子、草果及甘草10味药组成,记载散煎煮方法与原文一致的有20条,即煎煮时以姜枣为药引;共26本中医古籍中记载实脾散功效主治,其记载多数与原文一致,即“治阴水,先实脾土”。现代研究文献共筛选文献168篇,根据纳入标准与排除标准,最终所得37篇文献,均为实脾散临床应用研究,目前暂未有关于实脾散的药理药效学研究,实脾散的作用机制尚不明确,现代临床可用于治疗腹水、心力衰竭、腹泻、中心性浆液性脉络膜视网膜病变、慢性肾炎、结节性红斑、失代偿肝硬变、小儿维生素B_(1)缺乏症、老年慢性支气管炎等病。结论:历代医家在使用实脾散时多遵照原方,治疗“阴水”疗效突出,现代临床应用范围逐渐扩大,但病症总与“水、湿、痰”有关。实脾散作用机制尚处于空白状态,建议可在网络药理学预测的基础上,开展基础实验研究,为其临床合理应用提供科学的依据。
Objective:To clarify the composition and application of the classic famous prescription Shipi Powder,to provide documentary evidence support for its clinical application in traditional Chinese medicine and theoretical basis for the research and development of compound preparation.Methods:Bibliometric method was used to search ancient books through Chinese Medical Code Database(V5.0)and modern research documents through China National Knowledge Infrastructure(CNKI),China Biomedical Database(CBM),and China Science Periodical Database(CSPD),with“实脾散”(Shipi Powder)and“实脾饮”(Shipi Decoction)as key words.The retrieval time was from the inception of the databases to February 2020.References were screened according to inclusion and exclusion criteria.Results:A total of 89 ancient books were collected,including 26 ancient Chinese medicine books(1 in Song Dynasty,1 in Yuan Dynasty,16 in Ming Dynasty and 8 in Qing Dynasty).There were 19 prescriptions that were consistent with Shipi Powder in this paper in composition,namely Cortex Magnoliae Offcinalis,Rhizoma Atractylodis Macrocephalae,Poria,Fructus Chaenomelis,Radix Aucklandiae,Rhizoma Zingiberis,Radix Aconiti Lateralis Praeparata,Semen Arecae,Fructus Tsaoko,and Radix Et Rhizoma Glycyrrhizae(10 medicinal herbs in total).There werE_(2)0 prescriptions that had same decoction method with Shipi Powder in this paper,that is,using ginger and jujube as extra conducive components during decoction process.The efficacy of Shipi Powder was recorded in 26 ancient Chinese medicine books,and most of them conformed to this paper,that is,“treating yin edema by consolidating the earth(spleen)firstly”.A total of 168 modern research documents were screened,and 37 were finally obtained according to the inclusion and exclusion criteria,all of which were the clinical application of Shipi Powder.At present,little is known about the pharmacology and pharmacodynamics of Shipi Powder,and its mechanism of action remains unclear.In modern clinical practice,Shipi Powder has been
作者
华姞安
高学敏
孟靓
贾岚
王蕾蕾
张瑞贤
王景霞
HUA Ji′an;GAO Xuemin;MENG Liang;JIA Lan;WANG Leilei;ZHANG Ruixian;WANG Jingxia(Beijing University of Chinese Medicine,Beijing 100029,China;China Academy of Chinese Medical Sciences,Beijing 100700,China)
出处
《世界中医药》
CAS
2022年第23期3384-3389,3396,共7页
World Chinese Medicine
基金
国家自然科学基金项目(81202934)。
关键词
实脾散
历史沿革
中华医典数据库
方义分析
现代临床应用
Shipi Powder
Historical evolution
Chinese Medical Code Database
Prescription analysis
Modern clinical application
