摘要
目的观察左旋维生素C联合逍遥散加减治疗黄褐斑的临床疗效及其对患者氧化应激反应的影响。方法选取2019年6月—2021年1月南昌大学第一附属医院高新医院收治的100例黄褐斑患者作为研究组,采用随机数字表法分为亚组1和亚组2,各50例。另选取本院同期体检健康人员20例作为健康对照组。亚组1采用左旋维生素C治疗,亚组2在亚组1基础上联合逍遥散加减治疗。2组均持续治疗3个疗程。比较亚组1和亚组2临床疗效,治疗前及治疗12周黄褐斑面积及严重程度(MASI)评分、血清氧化应激指标[丙二醛(MDA)、脂质过氧化物(LPO)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)]水平及不良反应发生情况,并比较研究组与健康对照组血清氧化应激指标。结果亚组2总有效率为92.00%,高于亚组1的70.00%(χ^(2)=7.862,P=0.005)。治疗后12周,2组MASI评分低于治疗前,且亚组2低于亚组1(P<0.01)。研究组治疗前血清MDA、LPO水平高于健康对照组,血清SOD及GSH-Px水平低于健康对照组(P<0.01)。治疗后12周,亚组1与亚组2血清LPO水平低于治疗前,血清SOD和GSH-Px水平高于治疗前,亚组2血清MDA水平低于治疗前,且亚组2上述指标均优于亚组1(P<005)。2组均未发生明显不良反应。结论左旋维生素C联合逍遥散加减治疗黄褐斑的临床疗效确切,可更有效地减轻皮损程度,改善氧化应激水平,减轻过氧化损伤,且安全性较高。
Objective To investigate the clinical effect of L-vitamin C combined withXiaoyaopowder modified in the treatment of chloasma and its impact on oxidative stress reaction of patients.Methods A total of 100 patients with chloasma admitted to Gaoxin Hospital of the First Affiliated Hospital of Nanchang University from June 2019 to January 2021 were select-ed as study group,and they were divided into subgroup 1 and subgroup 2 according to random number table method,with50 cases in each group.Another 20 healthy volunteers were selected in the same period as the healthy group.Patients in subgroup 1 were treated with L-vitamin C,and patients in subgroup 2 were treated withXiaoyaopowder modified,both groups were treated 3 courses.Clinical efficacy,MASI score,serum oxidative stress indexes(MDA,LPO,SOD,GSH-Px)before treatment and at 12 weeks after treatment,incidence of adverse reactions were compared between the subgroup 1 and subgroup2,and serum oxidative stress indexes were compared between the study group and the control group.Results Total effective rate of subgroup 2 was 92.00%,which was higher than 70.00%of subgroup 1(χ^(2)=7.862,P=0.005).At 12 weeks after treatment,MASI score in the two groups was lower than that before treatment,and that in subgroup 2 was lower than subgroup1(P<0.01).Serum levels of MDA,LPO before treatment in study group were higher than those in control group,serum levels of SOD,GSH-Px were lower than those in control group(P<0.01).At 12 weeks after treatment,serum level of LPO in the subgroup 1 and subgroup 2 was lower than that before treatment,serum levels of SOD and GSH-Px were higher than those before treatment,and serum level of MDA in subgroup 2 was lower than that before treatment,and those in subgroup 2 were better than subgroup 1(P<0.05).There was no obvious adverse reactions in the two groups.Conclusion L-vitamin C combined withXiaoyaopowder modified have significant efficacy in the treatment of chloasma,which can more effectively reduce skin lesion degree,improve the level of oxidati
作者
吴晨雯
郑国钰
许亚超
WU Chenwen;ZHENG Guoyu;XU Yachao(Department of Medical Cosmetology,Gaoxin Hospital of the First Afiliated Hospital of Nanchang University,Nanchang 330000,China;不详)
出处
《临床合理用药杂志》
2022年第27期59-62,共4页
Chinese Journal of Clinical Rational Drug Use
